Blocking of the IL-33/ST2 Signaling Axis by a Single-Chain Antibody Variable Fragment

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Each IL-17A and IL-17F

  • Interleukin (IL)-17A is a key driver of irritation and the principal goal of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally related member of the family IL-17F, have been proven to be functionally dysregulated in sure human immune-mediated inflammatory ailments comparable to psoriasis, psoriatic arthritis, and axial spondyloarthritis. Given the overlapping biology of those two cytokines, we postulated that twin neutralization of IL-17A and IL-17F could present a larger depth of medical response in IL-17-mediated ailments than IL-17A inhibition alone.
  • We recognized 496.g1, a humanized antibody with sturdy affinity for IL-17A however poor affinity for IL-17F. Affinity maturation of 496.g1 to 496.g3 drastically enhanced the affinity of the Fab fragment for IL-17F whereas retaining sturdy binding to IL-17A. As an IgG1, the affinity for IL-17A and IL-17F was 3.2 pM and 23 pM, respectively.
  • Comparability of 496.g3 IgG1 with the commercially accessible anti-IL-17A monoclonal antibodies ixekizumab and secukinumab, by floor plasmon resonance and in a human in vitroIL-17A practical assay, confirmed that 496.g3 and ixekizumab show equal affinity for IL-17A, and that each antibodies are markedly stronger than secukinumab. In distinction to ixekizumab and secukinumab, 496.g3 exhibited the distinctive function of additionally with the ability to neutralize the organic exercise of IL-17F.
  • Due to this fact, antibody 496.g3 was chosen for medical growth for its potential to neutralize the biologic perform of each IL-17A and IL-17F and was renamed bimekizumab (previously UCB4940). Early medical information in sufferers with psoriasis, in these with psoriatic arthritis, and from the Section 2 research in psoriasis, psoriatic arthritis, and ankylosing spondylitis, are encouraging and assist the focused method of twin neutralization of IL-17A and IL-17F. Taken collectively, these findings present the rationale for the continued medical analysis of bimekizumab in sufferers with immune-mediated inflammatory ailments.

 

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LIF, mouse

MO16102 100 ug
EUR 810

LIF, Mouse

HY-P7084 50ug
EUR 639.6

Anti-Mouse LIF Antibody

103-M263 100 µg
EUR 399
Description: Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts.

Anti-Mouse LIF Antibody

103-PA05S 100 µg
EUR 126
Description: Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, though mouse LIF is about 1000 fold less active on human cells, than human LIF.

Rabbit Anti-Mouse LIF

103-PA05 100ug
EUR 240

Mouse LIF Protein

E40MOP1672 20ug
EUR 495

Mouse LIF Protein

E40MOP2026 20ug
EUR 495

Mouse LIF Protein

E40MOP2028 20ug
EUR 495

Recombinant Mouse LIF

Z200195 10 µg
EUR 85
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Mouse LIF

Z200197 100 µg
EUR 385
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation. It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1. The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Mouse LIF

Z200199 1.0 mg
EUR 1200
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation (2). It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1 (2). The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

Recombinant Mouse LIF

Z200485 100 µg
EUR 1500
Description: LIF is a multifunctional secreted glycoprotein that exists in both soluble and matrix-bound forms. It displays biologic activities ranging from the differentiation of myeloid leukemic cells into macrophage lineage to effects on bone metabolism, inflammation, neural development, embryogenesis, and the maintenance of implantation (2). It is now clear that LIF is related in both structure and mechanism of action to the interleukin IL-6 family of cytokines, which also includes IL-11, ciliary neurotrophic factor, oncostatin M, and cardiotrophin 1 (2). The actions of these cytokines are mediated through specific cell-surface receptors that consist of a unique chain and the shared signal transducing subunit gp130.

anti- LIF antibody

FNab09804 100µg
EUR 658.5
Description: Antibody raised against LIF

anti- LIF antibody

LSMab09804 100 ug
EUR 463.2

Mouse LIF ELISA Kit

EML0014 96Tests
EUR 625.2

Mouse LIF ELISA Kit

EK5250 96 tests
EUR 599

Mouse LIF ELISA Kit

E28L0650 96T
EUR 666.67

Rat Monoclonal anti-mouse LIF

mAP-0122 100ug
EUR 250

Sheep Polyclonal anti-mouse LIF

mAP-5260 50ug
EUR 400

Mouse LIF shRNA Plasmid

20-abx971321
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  • 150 µg
  • 300 µg

Mouse LIF Recombinant Protein

M30-007 10 µg
EUR 99.75
Description: Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, though mouse LIF is about 1000 fold less active on human cells, than human LIF. Recombinant mouse LIF produced in E. coli is a single, non-glycosylated, polypeptide chain containing 180 amino acids and having a molecular mass of 19.86 kDa.

Mouse LIF Recombinant Protein

M30-008 50 µg
EUR 246.75
Description: Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, though mouse LIF is about 1000 fold less active on human cells, than human LIF. Recombinant mouse LIF produced in E. coli is a single, non-glycosylated, polypeptide chain containing 180 amino acids and having a molecular mass of 19.86 kDa.

Recombinant Mouse LIF Protein

R01400-1 100ug/vial
EUR 352.8

Recombinant Mouse LIF Protein

PKSM041100-100ug 100ug
EUR 739
Description: Mouse

Recombinant Mouse LIF Protein

PKSM041100-20ug 20ug
EUR 249
Description: Mouse

Mouse LIF PicoKine ELISA Kit

EK0580 96 wells
EUR 510
Description: For quantitative detection of mouse LIF in cell culture supernates, serum and plasma (heparin, EDTA).

Anti-Human LIF Antibody

102-PA05S 100 µg
EUR 126
Description: Leukemia Inhibitory Factor also called LIF is a lymphoid factor that promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo. Human and mouse LIF exhibit a 78% identity in its amino acid sequence. Human LIF is as active on human cells as is it is on mouse cells, though mouse LIF is about 1000 fold less active on human cells, than human LIF.

Anti-Human LIF Antibody

101-M553 100 µg
EUR 399
Description: Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts.

LIF mouse monoclonal antibody, clone 4F7.2

MO16101-100 100 µg Ask for price

LIF mouse monoclonal antibody, clone 2H2.2

MO16102-100 100 µg Ask for price

Lif ORF Vector (Mouse) (pORF)

ORF049145 1.0 ug DNA
EUR 607.2

Lif ORF Vector (Mouse) (pORF)

ORF049146 1.0 ug DNA
EUR 607.2

Rabbit Anti-Human LIF

102-PA05 100ug
EUR 240

LIF, Mouse Recombinant , 1MIU/ml

L4500-001 1ml
EUR 406.8

LIF, Mouse Recombinant , 1MIU/ml

L4500-005 5x1ml
EUR 1431.6

LIF ELISA Kit (Mouse) (OKBB00760)

OKBB00760 96 Wells
EUR 606
Description: Description of target: Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate. The LIF was mapped gene to 22q11-q12.2 by Southern analysis of a series of mouse/human somatic cell hybrids and by in situ hybridization to the chromosomes of 2 normal males and some individuals with chromosomal rearrangements. The gene maps between the Philadelphia translocation BCR1 and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF derives its name from its ability to induce the terminal differentiation of myeloid leukemic cells, thus preventing their continued growth. Other properties attributed to the cytokine include: the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

LIF ELISA Kit (Mouse) (OKEH04045)

OKEH04045 96 Wells
EUR 652.8
Description: Description of target: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.039 ng/mL

LIF, Mouse Recombinant , 10MIU/ml

L4501-001 1ml
EUR 1744.8

Nori® Mouse LIF ELISA Kit

GR117058 96-well
EUR 461

Mouse LIF Recombinant Protein Lyophilized

IMSLIFRLY5UG each
EUR 317
Description: Mouse LIF Recombinant Protein Lyophilized

Human CellExp? LIF, mouse recombinant

7268-10 each
EUR 444

Mouse LIF protein, C-His tag

PRP1126-100ug 100 μg
EUR 379
Description: Mouse LIF protein, C-His tag, expressed in E. coli

Mouse LIF protein, C-His tag

PRP1126-1mg 1 mg
EUR 2509
Description: Mouse LIF protein, C-His tag, expressed in E. coli

Mouse LIF protein, C-His tag

PRP1126-20ug 20 μg
EUR 149
Description: Mouse LIF protein, C-His tag, expressed in E. coli

Mouse LIF protein, C-His tag

PRP1126-5ug 5 μg
EUR 59
Description: Mouse LIF protein, C-His tag, expressed in E. coli

Leukemia Inhibitory Factor (LIF), mouse

PR16102 5 ug
EUR 522

Leukemia Inhibitory Factor (LIF), mouse

PR16102-B each
EUR 436.5

Lif (untagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 1, (10ug)

MC208887 10 µg Ask for price

Lif (untagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 2, (10ug)

MC208888 10 µg Ask for price

Recombinant Mouse Lif Protein, No Tag

E40MOP2217 20ug
EUR 495

Lif (GFP-tagged) - Mouse leukemia inhibitory factor (Lif) transcript variant 2, (10ug)

MG223901 10 µg Ask for price

Lif (GFP-tagged) - Mouse leukemia inhibitory factor (Lif) transcript variant 1, (10ug)

MG223120 10 µg Ask for price

Lif (Myc-DDK-tagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 1

MR223120 10 µg Ask for price

Lif (Myc-DDK-tagged) - Mouse leukemia inhibitory factor (Lif), transcript variant 2

MR223901 10 µg Ask for price

OKBB00760-96W - LIF ELISA Kit (Mouse)

OKBB00760-96W 96wells
EUR 538

OKEH04045-96W - LIF ELISA Kit (Mouse)

OKEH04045-96W 96Wells
EUR 425

Lif sgRNA CRISPR Lentivector set (Mouse)

K3872501 3 x 1.0 ug
EUR 406.8

Sheep Polyclonal anti-human LIF

hAP-5294 50ug
EUR 400

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse)

4-PAA085Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF)

LIF, Leukemia inhibitory factor, murine (mouse)

RC234-18 5ug
EUR 125.26

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-1mg 1 mg
EUR 3801.6

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-3x10g 3x10 µg
EUR 393.6

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-3x2g 3x2 µg
EUR 276

Mouse Leukemia Inhibitory Factor (LIF) Protein

20-abx067761
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-10mg 10 mg
EUR 325

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-25mg 25 mg
EUR 3287.5

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx262959-5mg 5 mg
EUR 225

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx067761-100g 100 µg
EUR 550

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx067761-10g 10 µg
EUR 212.5

Mouse Leukemia Inhibitory Factor (LIF) Protein

abx067761-50g 50 µg
EUR 387.5

Mouse LIF Protein, His Tag (MALS verified)

LIF-M5227 1mg
EUR 321
Description: Mouse LIF, His Tag (LIF-M5227) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Phe 203 (Accession # P09056-1).

Mouse LIF Flow Cytometry Assay - Group 3

MX85121 96 Tests
EUR 270

Mouse LIF Protein, Tag Free (MALS verified)

LIF-M5219 20ug
EUR 2856.9
Description: Mouse LIF Protein, Tag Free (LIF-M5219) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Phe 203 (Accession # P09056-1).

LIF Antibody

6245-002mg 0.02 mg
EUR 206.18
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

LIF Antibody

6245-01mg 0.1 mg
EUR 523.7
Description: LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.

LIF Antibody

25283-100ul 100ul
EUR 468

LIF Antibody

1-CSB-PA012928ESR2HU
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  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: ELISA

LIF Antibody

E036950 100μg/100μl
EUR 255
Description: Available in various conjugation types.

LIF Antibody

F49998-0.08ML 0.08 ml
EUR 140.25
Description: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface.

LIF Antibody

F49998-0.4ML 0.4 ml
EUR 322.15
Description: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface.

LIF Antibody

E38PA4058 100ul
EUR 225
Description: Available in various conjugation types.

LIF Antibody

E315544 100ug/200ul
EUR 295
Description: Available in various conjugation types.

LIF Antibody

E91288 100μg
EUR 255
Description: Available in various conjugation types.

LIF Antibody

DF13730 100ul
EUR 420

LIF Antibody

DF13730-100ul 100ul
EUR 280

LIF Antibody

DF13730-200ul 200ul
EUR 350

LIF Antibody

1-CSB-PA004761
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  • 100ug
  • 50ug
Description: A polyclonal antibody against LIF. Recognizes LIF from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

LIF Antibody

36950 100ul
EUR 319

LIF Antibody

36950-100ul 100ul
EUR 302.4

LIF Antibody

5216-100 each
EUR 379.2

LIF Antibody

5216-30T each
EUR 175.2

LIF antibody

70R-14100 100 ug
EUR 519
Description: Affinity purified Rabbit polyclonal LIF antibody

LIF antibody

70R-6230 50 ug
EUR 467
Description: Rabbit polyclonal LIF antibody

LIF antibody

70R-51295 100 ul
EUR 242
Description: Purified Polyclonal LIF antibody

LIF antibody

70R-12299 100 ug
EUR 343
Description: Rabbit polyclonal LIF antibody

LIF Antibody

1-CSB-PA198481
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  • 100ul
  • 50ul
Description: A polyclonal antibody against LIF. Recognizes LIF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:10000, IHC:1:25-1:100

LIF Antibody

GWB-MT498C 50ug Ask for price

LIF Antibody

R30639 100 ug
EUR 356.15
Description: LIF is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play an essential role in implantation in mice. It is produced in high amounts by the human endometrium and the trophoblast itself, and its receptors are present on cytotrophoblast cells. LIF could thus play a role in modulating HLA-G production and immune tolerance at the maternal-fetal interface. The gene maps to 22q11-q12.2, between the Philadelphia translocation BCR gene and the breakpoint of the translocation in cell line GM2324 at 22q12.2.

LIF Antibody

R31467 100 ug
EUR 356.15
Description: LIF is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play an essential role in implantation in mice. This gene is mapped to 22q11-q12.2, between the Philadelphia translocation BCR gene and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF is produced in high amounts by the human endometrium and the trophoblast itself, and LIF receptors are present on cytotrophoblast cells. It could, thus, play a role in modulating HLA-G production and immune tolerance at the maternal-fetal interface.

LIF Antibody

R36251-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Leukemia inhibitory factor

LIF antibody

PAab09804 100 ug
EUR 463.2

Recombinant Mouse Leukemia Inhibitory Factor/lIF

AP75318 1mg
EUR 3209

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-10ug 10ug
EUR 175.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

Recombinant Mouse Leukemia Inhibitory Factor/lIF

C690-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

LIF Protein Vector (Mouse) (pPM-C-HA)

PV196580 500 ng
EUR 723.6

LIF Protein Vector (Mouse) (pPM-C-HA)

PV196584 500 ng
EUR 723.6

LIF

E8ER1912-32 100ul
EUR 275
Description: Available in various conjugation types.

LIF

cyt-644 5µg
EUR 60
Description: Recombinant Human Leukemia Inhibitory Factor

LIF Protein Vector (Mouse) (pPB-C-His)

PV196578 500 ng
EUR 723.6

LIF Protein Vector (Mouse) (pPB-N-His)

PV196579 500 ng
EUR 723.6

LIF Protein Vector (Mouse) (pPM-C-His)

PV196581 500 ng
EUR 723.6

LIF Protein Vector (Mouse) (pPB-C-His)

PV196582 500 ng
EUR 723.6

LIF Protein Vector (Mouse) (pPB-N-His)

PV196583 500 ng
EUR 723.6

LIF Protein Vector (Mouse) (pPM-C-His)

PV196585 500 ng
EUR 723.6

Mouse LIF -Leukemia Inhibitory Factor- CLIA Kit

E-CL-M0038-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse LIF -Leukemia Inhibitory Factor- CLIA Kit

E-CL-M0038-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse LIF -Leukemia Inhibitory Factor- CLIA Kit

E-CL-M0038-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse LIF -Leukemia Inhibitory Factor- CLIA Kit

E-CL-M0038-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse LIF -Leukemia Inhibitory Factor- CLIA Kit

E-CL-M0038-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Anti-Human LIF R alpha Antibody

101-M554 100 µg
EUR 399
Description: The activities of the pleiotropic cytokine LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

Mouse Lif/ Leukemia inhibitory factor ELISA Kit

E1656Mo 1 Kit
EUR 543
Description: Differentiation-stimulating factor,D factor

Mouse Lif(Leukemia inhibitory factor) ELISA Kit

EM0237 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.9pg/ml

Mouse Lif / Leukemia inhibitory factor ELISA Kit

E0085m 96T
EUR 776

anti-LIF

YF-PA12952 50 ug
EUR 435.6
Description: Mouse polyclonal to LIF

Mouse LIF Protein (Ser 24-Phe 203) [His]

VAng-1946Lsx-20g 20 µg
EUR 588
Description: Mouse LIF protein, His tag, expressed in human 293 cells. (Uniprot ID: P09056)

Mouse LIF Protein (Ser 24-Phe 203) [His]

VAng-1946Lsx-50g 50 µg
EUR 1050
Description: Mouse LIF protein, His tag, expressed in human 293 cells. (Uniprot ID: P09056)

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), PE

4-PAA085Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with PE.

Recombinant Mouse LIF Protein, Untagged, E.coli-1mg

QP4235-1mg 1mg
EUR 3189.6

Recombinant Mouse LIF Protein, Untagged, E.coli-5ug

QP4235-5ug 5ug
EUR 163.2

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), APC

4-PAA085Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with APC.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), Cy3

4-PAA085Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with Cy3.

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), HRP

4-PAA085Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with HRP.

Mouse LIF Recombinant Protein Tag Free Lyophilized

IMSLIFRTFLY50UG each
EUR 681
Description: Mouse LIF Recombinant Protein Tag Free Lyophilized

Recombinant Mouse LIF Protein, Untagged, E.coli-20ug

QP4235-20ug 20ug
EUR 284.4

Leukemia Inhibitory Factor (LIF) Polyclonal Antibody (Mouse), FITC

4-PAA085Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Leukemia Inhibitory Factor (LIF). This antibody is labeled with FITC.

Recombinant Mouse LIF Protein, Untagged, E.coli-100ug

QP4235-100ug 100ug
EUR 729.6

Recombinant Mouse LIF Protein, Untagged, E.coli-500ug

QP4235-500ug 500ug
EUR 1992

Lif sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3872502 1.0 ug DNA
EUR 184.8

Lif sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3872503 1.0 ug DNA
EUR 184.8

Lif sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3872504 1.0 ug DNA
EUR 184.8

Mouse Leukemia Inhibitory Factor (LIF) CLIA Kit

abx195395-96tests 96 tests
EUR 990

Mouse LIF Recombinant Protein (Animal Free) Lyophilized

IMSLIFRAFLY5UG each
EUR 333
Description: Mouse LIF Recombinant Protein (Animal Free) Lyophilized

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Mu 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Mu-48T 48T
EUR 586.8
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

DLR-LIF-Mu-96T 96T
EUR 762
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Leukemia Inhibitory Factor (LIF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Leukemia inhibitory factor,LIF Elisa kit

EK731218 96 Wells
EUR 0.76

Mouse Leukemia inhibitory factor,LIF ELISA kit

EKC37279-48T 48T
EUR 631.26

Mouse Leukemia inhibitory factor,LIF ELISA kit

EKC37279-5x96T 5x96T
EUR 4283.55

Mouse Leukemia inhibitory factor,LIF ELISA kit

EKC37279-96T 96T
EUR 901.8

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

EKU11866-48T 48T
EUR 514.08

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

EKU11866-5x96T 5x96T
EUR 3488.4

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

EKU11866-96T 96T
EUR 734.4

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

EKN52977-48T 48T
EUR 320.04

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

EKN52977-5x96T 5x96T
EUR 2171.7

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

EKN52977-96T 96T
EUR 457.2

Mouse Leukemia inhibitory factor(LIF)ELISA Kit  

GA-E0658MS-48T 48T
EUR 403.2

Mouse Leukemia inhibitory factor(LIF)ELISA Kit  

GA-E0658MS-96T 96T
EUR 640.8

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

DL-LIF-Mu 96T
EUR 412
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

EK15237 96Т
EUR 768

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

abx574566-96tests 96 tests
EUR 904.8

Mouse Leukemia inhibitory factor, LIF ELISA kit

CSB-E04652m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Leukemia inhibitory factor, LIF in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Leukemia inhibitory factor, LIF ELISA kit

1-CSB-E04652m
  • Ask for price
  • Ask for price
  • Ask for price
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Leukemia inhibitory factor, LIF in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Leukemia inhibitory factor,LIF ELISA kit

CN-02441M1 96T
EUR 560.4

Mouse Leukemia inhibitory factor,LIF ELISA kit

CN-02441M2 48T
EUR 379.2

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

abx254611-96tests 96 tests
EUR 904.8

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Mu-48T 48T
EUR 422.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Mu-48Tests 48 Tests
EUR 586.8

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Mu-96T 96T
EUR 603.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RD-LIF-Mu-96Tests 96 Tests
EUR 812.4

Mouse Leukemia inhibitory factor (LIF) ELISA Kit

RK06174 96T
EUR 280

Mouse leukemia inhibitory factor(LIF)ELISA Kit

QY-E20907 96T
EUR 433.2

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Mu-48T 48T
EUR 443.42
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Leukemia Inhibitory Factor (LIF) ELISA Kit

RDR-LIF-Mu-48Tests 48 Tests
EUR 613.2

 

Myelin oligodendrocyte glycoprotein-antibody (MOG-IgG) related illness with centrally positioned lengthy spinal wire lesion in a 14-month previous baby

Myelin oligodendrocyte glycoprotein-antibodies (MOG-IgG) are related to acquired inflammatory demyelinating syndromes, seen predominantly in youngsters and younger adults. The overlapping medical and radiological options of the heterogenous spectrum of demyelinating central nervous system (CNS) ailments makes the detection of MOG-IgG antibodies essential for prognosis and remedy choices.

Herein, we describe the incidence of MOG-IgG related illness presenting as acute disseminated encephalomyelitis (ADEM), with spinal MRI findings of centrally positioned lengthy wire lesion in a 14-month previous baby.

Auto-antibodies towards sort I IFNs in sufferers with life-threatening COVID-19

Interindividual medical variability in the middle of SARS-CoV-2 an infection is immense. We report that no less than 101 of 987 sufferers with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs towards IFN-ω (13 sufferers), the 13 varieties of IFN-α (36), or each (52), on the onset of important illness; a couple of additionally had auto-Abs towards the opposite three sort I IFNs.

The auto-Abs neutralize the power of the corresponding sort I IFNs to dam SARS-CoV-2 an infection in vitro. These auto-Abs weren’t present in 663 people with asymptomatic or delicate SARS-CoV-2 an infection and had been current in solely four of 1,227 wholesome people. Sufferers with auto-Abs had been aged 25 to 87 years and 95 had been males. A B cell auto-immune phenocopy of inborn errors of sort I IFN immunity underlies life-threatening COVID-19 pneumonia in no less than 2.6% of ladies and 12.5% of males.

 

Blocking of the IL-33/ST2 Signaling Axis by a Single-Chain Antibody Variable Fragment (scFv) Particular to IL-33 with a Outlined Epitope

 

Interleukin 33 (IL-33) is an IL-1 household cytokine that performs a central function in immune system by regulating and initiating inflammatory responses. The binding of IL-33 to the suppressor of tumorigenicity 2 (ST2) receptor induces mitogen-activated protein kinases (MAPK) and nuclear issue κB (NF-κB) pathways, thereby resulting in inflammatory cytokines manufacturing in sort 2 helper T cells and sort 2 innate lymphoid cells.

 

To develop an antibody particular to IL-33 with an outlined epitope, we characterised a single-chain antibody variable fragments (scFvs) clone particular to IL-33, C2_2E12, which was chosen from a human artificial library of scFvs utilizing phage show. Affinity (Okd) of C2_2E12 was decided to be 38 nM utilizing enzyme-linked immunosorbent assay. C2_2E12 didn’t present cross-reactivity towards different interleukin cytokines, together with intently associated IL-1 household cytokines and unrelated proteins.

 

Mutational scanning evaluation revealed that the epitope of IL-33 consisted of residues 149-158 with key residues being L150 and Ok151 of IL-33. Structural modeling instructed that L150 and Ok151 residues are essential for the interplay of IL-33 with C2_2E12, implicating that C2_2E12 may block the binding of ST2 to IL-33. Pull-down and in-cell assays supported that C2_2E12 can inhibit the IL-33/ST2 signaling axis. These outcomes recommend that the scFv clone characterised right here can perform as a neutralizing antibody.

 

Anti-Human IL-17 Antibody

101-M483 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Interleukin-17 (IL-17) Human

GWB-21DD5F 0.025 mg Ask for price

anti- IL-17 antibody

FNab04224 100µg
EUR 658.5
Description: Antibody raised against IL-17

anti- IL-17 antibody

FNab04225 100µg
EUR 606.3
Description: Antibody raised against IL-17

Anti-IL-17 Antibody

ER1706-91 100ul
EUR 189
Description: Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.

Anti-IL-17 antibody

PAab04224 100 ug
EUR 463.2

Anti-Human IL-17 receptor Antibody

101-M484 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Human IL-17 protein

PRP100289-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-1mg 1 mg
EUR 7139
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100289-5ug 5 μg
EUR 149
Description: Human IL-17 protein, expressed in E. coli

Human IL-17 protein

PRP100290-100ug 100 μg
EUR 1029
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-1mg 1 mg
EUR 6249
Description: Human IL-17 protein, expressed in CHO Stable Cells

Human IL-17 protein

PRP100290-5ug 5 μg
EUR 129
Description: Human IL-17 protein, expressed in CHO Stable Cells

Recombinant Human IL-17

HEILP-1702 5ug Ask for price

Recombinant Human IL-17

SJB09-03 25µg/vial
EUR 307.2

Anti-Mouse IL-17 Antibody

103-M411 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Anti-IL-17 alpha antibody

STJ93683 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-17Ralpha.

Anti-Human IL-17 (IL-17A) Goat Polyclonal Antibody

TA328238 100 µg Ask for price

Rabbit anti-IL-17 Antibody

DL90598A-100ul 100 ul
EUR 299
Description: CTLA8; IL17; Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Rabbit anti-IL-17 Antibody

DL90598A-50ul 50 ul
EUR 209.3
Description: CTLA8; IL17; Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8

Rabbit anti-IL-17 Antibody

YLD4293-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to IL-17

Rabbit anti-IL-17 Antibody

YLD4293-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to IL-17

Anti-Human IL-17 (IL-17A) Rabbit Polyclonal Antibody

TA328239 100 µg Ask for price

Human Interleukin 17 (IL-17) CLIA Kit

abx195860-96tests 96 tests
EUR 990

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-24Tests 24 Tests
EUR 180
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-48Tests 48 Tests
EUR 546
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests 96 Tests
EUR 682
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human IL-17 -Interleukin 17- CLIA Kit

E-CL-H0104-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human Interleukin 17,IL-17 ELISA Kit

201-12-0143 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-5x96T 5x96T
EUR 2667.6

Human IL-17 (Interleukin 17) ELISA Kit

EKE60099-96T 96T
EUR 561.6

Human Interleukin 17(IL-17) Elisa Kit

EK711084 96 Wells
EUR 0.14

Human IL-17(Interleukin 17) ELISA Kit

E39EH3267 96T
EUR 595

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H1 96T
EUR 520.8

Human Interleukin 17,IL-17 ELISA Kit

CN-03335H2 48T
EUR 340.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-48T 48T
EUR 346.8

Human Interleukin 17(IL-17)ELISA Kit

GA-E0081HM-96T 96T
EUR 559.2

Human Interleukin 17(IL-17) ELISA Kit

NSL1920Hu 96 wells
EUR 468

Human Interleukin 17(IL-17)ELISA Kit

QY-E04323 96T
EUR 433.2

Human Interleukin 17,IL-17 ELISA Kit

SL0978Hu 96 Tests
EUR 468

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-48T 48T Ask for price

Human Interleukin 17,IL-17 ELISA Kit

YLA1538HU-96T 96T Ask for price

Human Interleukin-17 (IL-17) ELISA Kit

IHUIL17KT each
EUR 702
Description: Human Interleukin-17 (IL-17) ELISA Kit

Human IL-17 /IL-17A ELISA kit

E22-HC170.48 48T
EUR 295

Human IL-17 /IL-17A ELISA kit

E22-HC170.96 96T
EUR 395

Recombinant Human Interleukin-17(rHu IL-17)

70117 25ul
EUR 235
Description: Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of > 1.3 × 105 IU/mg.

IL-17 Interleukin-17 Human Recombinant Protein

PROTQ16552-1 Regular: 25ug
EUR 380.4
Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa.  ;The IL-17 is purified by proprietary chromatographic techniques.

Recombinant Human IL-17 (IL-17A) Protein

PROTQ16552-4 25ug
EUR 380.4
Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.

Anti-Human IL-17 (CTLA-8) Antibody

101-M783 100 µg
EUR 399
Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

human IL-17, His tag

E410A10-100 100μg
EUR 700
Description: Inflammation Storm Cytokine

Human IL-17 ELISA Kit

E16HE0054 96T
EUR 733.33

Human IL-17 ELISA KIT

E16HE0054-048 48 wells
EUR 295

Human IL-17 ELISA KIT

E16HE0054-096 96 wells
EUR 395

IL-17 ELISA KIT|Human

EF006939 96 Tests
EUR 826.8

Human IL-17 ELISA KIT

E42EH-11 96T/48T Ask for price

IL-17 (Human) ELISA Kit

E4628-100 each
EUR 874.8

Human IL-17 ELISA Kit

GWB-ZZD054 1x96 well plate Ask for price

Human IL-17 ELISA kit

LF-EK50201 1×96T
EUR 777.6

Human IL-17 ELISA Kit

RK00397 96 Tests
EUR 280

Human IL-17 GENLISA ELISA

KBH0142 1 x 96 wells
EUR 286

Biotinylated Anti-Human IL-17 (IL-17A) Goat Polyclonal Antibody

TA328237 50 µg Ask for price

Biotinylated Anti-Human IL-17 (IL-17A) Rabbit Polyclonal Antibody

TA328236 50 µg Ask for price

CLIA kit for Human IL-17 (Interleukin 17)

E-CL-H0104 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human IL-17 (Interleukin 17)

E-EL-H0105 1 plate of 96 wells
EUR 452.4
Description: A sandwich ELISA kit for quantitative measurement of Human IL-17 (Interleukin 17) in samples from Serum, Plasma, Cell supernatant

Human Interleukin 17 (IL-17) Detection Assay Kit

6808 1 kit
EUR 357
Description: Culture Media, Serum, Plasma

IL-17 Interleukin-17 Human Recombinant Protein, HEK

PROTQ16552 Regular: 10ug
EUR 380.4
Description: IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.;The IL-17 is purified by proprietary chromatographic techniques.

Rat Anti-Mouse IL-17, Antibody

GWB-47F187 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-58C273 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-1DEA14 0.5 mg Ask for price

Rat Anti-Mouse IL-17, Antibody

GWB-F6EA7C 0.5 mg Ask for price

Anti-Mouse IL-17 receptor Antibody

103-M245 100 µg
EUR 399
Description: IL-17 binds to IL-17 receptors (IL-17 R), which share no homology with any known family of receptors. While the expression of IL-17 is restricted to activated T cells, IL-17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The amino acid sequence of human IL-17 R is 69% identical to mouse IL-17 R.

Rat Monoclonal anti-mouse IL-17

mAP-0262 100ug
EUR 250

Interleukin 17 (IL-17) Antibody

abx234224-100ug 100 ug
EUR 610.8

Interleukin 17 (IL-17) Antibody

abx234225-100ug 100 ug
EUR 577.2

IL-17/Interleukin-17, Antibody

GWB-F0E090 1 ml Ask for price

IL-17 Antibody

24784-100ul 100ul
EUR 468

IL-17 Antibody

24789-100ul 100ul
EUR 468

IL-17 Antibody

4877-002mg 0.02 mg
EUR 206.18
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4877-01mg 0.1 mg
EUR 523.7
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4887-002mg 0.02 mg
EUR 206.18
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 Antibody

4887-01mg 0.1 mg
EUR 523.7
Description: IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

IL-17 antibody

E39-04224 100ug/100ul
EUR 225
Description: Available in various conjugation types.

IL-17 antibody

CAF50560-100ug 100ug
EUR 338

IL-17 Antibody

5176-100 each
EUR 405.6

IL-17 Antibody

F42568-0.4ML 0.4 ml
EUR 322.15
Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

IL-17 Antibody

R35097-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Interleukin 17A; IL17A

IL-17 Antibody

R36188-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Interleukin 17A antibody, IL17A, CTLA8

Anti-CTLA-8 / IL-17a Reference Antibody (UCB anti-IL-17)

E24CHA778 100 μg
EUR 225
Description: Available in various conjugation types.

Mouse Monoclonal anti-human CTLA-8 (IL-17)

hAP-0372 100ug
EUR 250

Mouse Monoclonal anti-human CTLA-8 (IL-17)

hAP-0372A 100ug
EUR 250

Sheep Polyclonal anti-Human CTLA-8 (IL-17)

hAP-5814 50ug
EUR 400

ELISA kit for Human IL-17

KET6022-48T 48T
EUR 242.4
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-5platesof96wells 5 plates of 96 wells
EUR 1292.4
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human IL-17

KET6022-96T 96T
EUR 346.8
Description: Quantitative sandwich ELISA for measuring Human IL-17 in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human IL-17 ELISA kit (4X96T)

LF-EK50202 4×96T
EUR 2641.2

Human IL-17 protein, His Tag

PRP100287-100ug 100 μg
EUR 779
Description: Human IL-17 protein, His Tag, expressed in Baculovirus-Insect Cells

Human IL-17 protein, His Tag

PRP100287-1mg 1 mg
EUR 4959
Description: Human IL-17 protein, His Tag, expressed in Baculovirus-Insect Cells

Human IL-17 protein, His Tag

PRP100288-100ug 100 μg
EUR 779
Description: Human IL-17 protein, His Tag, expressed in Yeast

Human IL-17 protein, His Tag

PRP100288-1mg 1 mg
EUR 4959
Description: Human IL-17 protein, His Tag, expressed in Yeast

CymaxTM Human IL-17 ELISA Kit

LF-EK0295 1×96T
EUR 477.6

IL-17

E8ER1706-91 100ul
EUR 275
Description: Available in various conjugation types.

IL-17

EF014060 96 Tests
EUR 826.8

IL-17

E5-00007 1mg
EUR 700

IL-17

GWB-3B32E2 0.025 mg Ask for price

IL-17

PR27113 5 ug
EUR 229.2

IL-17

MO15110 500 ug
EUR 1092

IL-17

PR27113-B each
EUR 184.5

IL-17 Interleukin-17 Human Recombinant Protein, His Tag

PROTQ16552-2 Regular: 10ug
EUR 380.4
Description: Interleukin-17A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 132 amino acids fragment (24-155) having a molecular weight of 19.62kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. ;The IL-17A His is purified by proprietary chromatographic techniques.

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

EKC40888-48T 48T
EUR 535.99

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

EKC40888-5x96T 5x96T
EUR 3637.08

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

EKC40888-96T 96T
EUR 765.7

Human Interleukin 17A(IL-17A,IL-17) Elisa Kit

EK710278 96 Wells
EUR 0.78

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

CSB-E12819h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 17A (IL-17A/IL-17) ELISA Kit

1-CSB-E12819h
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 17A (IL-17A/IL-17) in samples from serum, urine, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human IL-17 /IL-17A ELISA kit (High Sensitivity)

E22-HC170(H).48 48T
EUR 495

Human IL-17 /IL-17A ELISA kit (High Sensitivity)

E22-HC170(H).96 96T
EUR 595

Anti‐Human IL‐17A

E2790213 100ul
EUR 225
Description: Available in various conjugation types.

IL-17/IL-17A

E21-021 10ug
EUR 225
Description: Recombinant Human Interleukin-17A is produced by our E.coli expression system and the target gene encoding Ile20-Ala155 is expressed.

Rat Monoclonal anti-mouse IL-17 Receptor

mAP-0104 100ug
EUR 250

Human IL-17 RB Protein, Fc Tag

ILB-H5251 1mg
EUR 374.5
Description: Human IL-17 RB, Fc Tag (ILB-H5251) is expressed from human 293 cells (HEK293). It contains AA Arg 18 - Pro 292 (Accession # Q9NRM6-1).

EliKine™ Human IL-17 ELISA Kit

KTE6022-48T 48 T
EUR 189
Description: EliKine™ Human IL-17 ELISA Kit employs a two-site sandwich ELISA to quantitate Human IL-17.

EliKine™ Human IL-17 ELISA Kit

KTE6022-96T 96 T
EUR 289
Description: EliKine™ Human IL-17 ELISA Kit employs a two-site sandwich ELISA to quantitate Human IL-17.

OKRC00573-96W - IL-17 ELISA Kit (Human)

OKRC00573-96W 96Wells
EUR 525

Mouse Monoclonal IL-17 RA/IL-17 R Antibody (49M4D2)

TA337125 100 µg Ask for price

Mouse Monoclonal IL-17 RA/IL-17 R Antibody (49M5D9)

TA337127 100 µg Ask for price

Mouse Monoclonal IL-17 RA/IL-17 R Antibody (49M7C6)

TA337128 100 µg Ask for price

Human Interleukin-17,IL-17A ELISA Kit

ELA-E1700h 96 Tests
EUR 988.8

Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

ILC-H5257 100ug
EUR 2749.9
Description: Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (ILC-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) (Accession # Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)).

Polyclonal IL-17 Antibody

APR06508G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

Polyclonal IL-17 Antibody

APR06512G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-17 . This antibody is tested and proven to work in the following applications:

Bovine Interleukin 17(IL-17)

QY-E60069 96T
EUR 511.2

Fish Interleukin 17-IL-17

QY-E160090 96T
EUR 580

Genorise® Anti-canine IL-17 Polyclonal Antibody

GR105162 100 ug
EUR 438

IL-17 Peptide

4877P 0.05 mg
EUR 197.7
Description: (NT) IL-17 peptide

IL-17 Peptide

4887P 0.05 mg
EUR 197.7
Description: (IN) IL-17 peptide

Mouse IL-17

GWB-ED9F68 0.025 mg Ask for price

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

AP76027 1mg
EUR 1319

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-10ug 10ug
EUR 120
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-1mg 1mg
EUR 1094.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-500ug 500ug
EUR 850.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc)

CI53-50ug 50ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

human anti-human IL-2 mAb

E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-4 mAb

E409C13-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb

E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-1β mAb

E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb

E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-12/IL-23 p40 mAb(3H2)

E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)

E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(1G11)

E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human IL-17 RA / CD217 Protein, Fc Tag

ILA-H5257 1mg
EUR 1166.3
Description: Human IL-17 RA Protein, Fc Tag (ILA-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1).

Human IL-17 RA / CD217 Protein, His Tag

ILA-H5222 1mg
EUR 299.6
Description: Human IL-17 RA, His Tag (ILA-H5222) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1).

Human IL-17A(Interleukin 17 A) ELISA Kit

EH3267 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human IL-17 F(Interleukin 17F) ELISA Kit

EKF59467-48T 48T
EUR 396.9

Human IL-17 F(Interleukin 17F) ELISA Kit

EKF59467-5x96T 5x96T
EUR 2693.25

Human IL-17 F(Interleukin 17F) ELISA Kit

EKF59467-96T 96T
EUR 567

Human IL-17A(Interleukin 17 A) ELISA Kit

EKF57643-48T 48T
EUR 396.9

Human IL-17A(Interleukin 17 A) ELISA Kit

EKF57643-5x96T 5x96T
EUR 2693.25

Human IL-17A(Interleukin 17 A) ELISA Kit

EKF57643-96T 96T
EUR 567

OKRC00574-96W - Il-17 B ELISA Kit (Human)

OKRC00574-96W 96Wells
EUR 525

OKRC00575-96W - IL-17 RB ELISA Kit (Human)

OKRC00575-96W 96Wells
EUR 525

OKRC00576-96W - IL-17 E ELISA Kit (Human)

OKRC00576-96W 96Wells
EUR 525

OKRC00578-96W - IL-17 R ELISA Kit (Human)

OKRC00578-96W 96Wells
EUR 525