Backside-up pattern preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices

Therapeutic monoclonal antibodies (mAbs) are quickly taking up the therapy of many malignancies, and an astonishing variety of mAbs is in improvement. This causes a excessive demand for quantification of mAbs in biomatrices each for measuring therapeutic mAb concentrations and to assist pharmacokinetics and pharmacodynamics research.

Conventionally, ligand-binding assays are used for these functions, however LC-MS is gaining recognition. Though intact (top-down) and subunit (middle-down) mAb quantification is reported, signature peptide (bottom-up) quantification is at present most advantageous.

This evaluation gives an outline of the reported bottom-up mAb quantification strategies in biomatrices in addition to common suggestions relating to signature peptide and inside commonplace choice, reagent use and optimization of digestion in bottom-up quantification strategies.

Anti-Human Resistin
MBS550711-01mg	MyBiosource	0.1mg	EUR 260

Anti-Human Resistin
MBS550711-02mg	MyBiosource	0.2mg	EUR 335

Human Resistin
90233-A	BPS Bioscience	5 µg	EUR 130
Description: Recombinant Resistin is a disulfide-linked homodimeric protein consisting of two 93 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing conditions and as a 10 kDa protein under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Resistin mature chain was expressed in E. coli.

Human Resistin
90233-B	BPS Bioscience	25 µg	EUR 205
Description: Recombinant Resistin is a disulfide-linked homodimeric protein consisting of two 93 amino acid residues, and migrates as an approximately 20 kDa protein under non-reducing conditions and as a 10 kDa protein under reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human Resistin mature chain was expressed in E. coli.

Human Resistin
MBS692069-0005mg	MyBiosource	0.005mg	EUR 300

Human Resistin
MBS692069-0025mg	MyBiosource	0.025mg	EUR 450

Human Resistin
MBS692069-5x0025mg	MyBiosource	5x0.025mg	EUR 1725

Human resistin
MBS400069-001mg	MyBiosource	0.01mg	EUR 220

Human resistin
MBS400069-005mg	MyBiosource	0.05mg	EUR 545

Human resistin
MBS400069-01mg	MyBiosource	0.1mg	EUR 770

Human resistin
MBS400069-1mg	MyBiosource	1mg	EUR 3830

Human Resistin Antibody
32138-05111	AssayPro	150 ug	EUR 215

Human Resistin Antibody
GWB-F7AAE4	GenWay Biotech	0.1 mg	Ask for price

Resistin (43-65) (Human) - Antibody
H-028-39	PHOENIX PEPTIDE	50 μl	EUR 604.8

Resistin (51-108) (Human) - Antibody
H-028-40	PHOENIX PEPTIDE	50 μl	EUR 604.8

Resistin (43-65) (Human)
028-39	PHOENIX PEPTIDE	100 μg	EUR 255.96

Resistin (51-108) (Human)
028-40	PHOENIX PEPTIDE	20 μg	EUR 282.96

Resistin (23-42) (Human)
028-41	PHOENIX PEPTIDE	100 μg	EUR 214.92

Resistin (25-42) (Human)
028-42	PHOENIX PEPTIDE	100 μg	EUR 214.92

Mouse Anti-Human Resistin
MBS690775-05mg	MyBiosource	0.5mg	EUR 525

Mouse Anti-Human Resistin
MBS690775-5x05mg	MyBiosource	5x0.5mg	EUR 2080

Anti-Human Resistin Antibody
101-M170	ReliaTech	500 µg	EUR 246.75
Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant human Resistin is a 19.5 kDa disulfide-linked homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond.

Anti-Human Resistin Antibody
101-M618	ReliaTech	100 µg	EUR 399
Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis.

Anti-Human Resistin Antibody
102-P92G	ReliaTech	100 µg	EUR 245.7
Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis.

Human Resistin (RETN)
1-CSB-EP019573HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Resistin(RETN) expressed in E.coli

Human resistin antagonist
MBS400115-001mg	MyBiosource	0.01mg	EUR 220

Human resistin antagonist
MBS400115-005mg	MyBiosource	0.05mg	EUR 545

Human resistin antagonist
MBS400115-01mg	MyBiosource	0.1mg	EUR 770

Human resistin antagonist
MBS400115-1mg	MyBiosource	1mg	EUR 3830

Biotinylated Anti-Human Resistin
GWB-BIG87D	GenWay Biotech	1 kit	Ask for price

Recombinant Human Resistin
7-01519	CHI Scientific	5µg	Ask for price

Recombinant Human Resistin
7-01520	CHI Scientific	25µg	Ask for price

Recombinant Human Resistin
7-01521	CHI Scientific	1mg	Ask for price

RECOMBINANT HUMAN RESISTIN
GWB-F4A137	GenWay Biotech	0.02 mg	Ask for price

Recombinant Human Resistin
cyt-456-1mg	ProSpec Tany	1mg	EUR 4680

Recombinant Human Resistin
cyt-456-25g	ProSpec Tany	25µg	EUR 145

Recombinant Human Resistin
cyt-456-5g	ProSpec Tany	5µg	EUR 60

Recombinant Human Resistin
MBS7611410-005mg	MyBiosource	0.05mg	EUR 345

Recombinant Human Resistin
MBS7611410-02mg	MyBiosource	0.2mg	EUR 635

Recombinant Human Resistin
MBS7611410-1mg	MyBiosource	1mg	EUR 1800

Recombinant Human Resistin
MBS7611410-5x1mg	MyBiosource	5x1mg	EUR 6955

Recombinant Human Resistin
MBS142332-0005mg	MyBiosource	0.005mg	EUR 240

Recombinant Human Resistin
MBS142332-0025mg	MyBiosource	0.025mg	EUR 310

Recombinant Human Resistin
MBS142332-1mg	MyBiosource	1mg	EUR 4895

Recombinant Human Resistin
MBS142332-5x1mg	MyBiosource	5x1mg	EUR 21695

Recombinant Human Resistin
MBS1410331-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 255

Recombinant Human Resistin
MBS1410331-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 405

Recombinant Human Resistin
MBS1410331-1mgEColi	MyBiosource	1mg(E-Coli)	EUR 1425

Recombinant Human Resistin
MBS1410331-5x1mgEColi	MyBiosource	5x1mg(E-Coli)	EUR 6215

RECOMBINANT HUMAN RESISTIN
MBS232425-0025mg	MyBiosource	0.025mg	EUR 510

RECOMBINANT HUMAN RESISTIN
MBS232425-5x0025mg	MyBiosource	5x0.025mg	EUR 2130

Human Resistin Recombinant
MBS553192-0005mg	MyBiosource	0.005mg	EUR 165

Human Resistin Recombinant
MBS553192-0025mg	MyBiosource	0.025mg	EUR 245

Recombinant Human Resistin
MBS9420612-002mg	MyBiosource	0.02mg	EUR 285

Recombinant Human Resistin
MBS9420612-01mg	MyBiosource	0.1mg	EUR 470

Recombinant Human Resistin
MBS9420612-1mg	MyBiosource	1mg	EUR 1785

Recombinant Human Resistin
MBS9420612-5x1mg	MyBiosource	5x1mg	EUR 7885

Human Resistin CLIA Kit
MBS8425884-INQUIRE	MyBiosource	INQUIRE	Ask for price

Resistin, human recombinant
4559-100	Biovision	each	EUR 874.8

Resistin, human recombinant
4559-1000	Biovision	each	EUR 6127.2

Resistin, human recombinant
4559-25	Biovision	each	EUR 307.2

Resistin (Recombinant) Human
GWB-8EE40A	GenWay Biotech	0.025 mg	Ask for price

Resistin, recombinant (Human)
028-36	PHOENIX PEPTIDE	20 μg	EUR 423.36

Resistin Human Recombinant
rAP-0727	Angio Proteomie	Inquiry	Ask for price

Human Resistin ELISA kit
E01R0351-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin ELISA kit
E01R0351-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin ELISA kit
E01R0351-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin ELISA kit
E01A7519	BlueGene	96T	EUR 700
Description: ELISA

Human Resistin ELISA Kit
E16HE0035	EnoGene	96T	EUR 833.33

Human Resistin ELISA KIT
E16HE0035-048	EnoGene	48 wells	EUR 295

Human Resistin ELISA KIT
E16HE0035-096	EnoGene	96 wells	EUR 395

Human Resistin ELISA KIT
EKC40240-48T	Biomatik Corporation	48T	EUR 412.02

Human Resistin ELISA KIT
EKC40240-5x96T	Biomatik Corporation	5x96T	EUR 2795.85

Human Resistin ELISA KIT
EKC40240-96T	Biomatik Corporation	96T	EUR 588.6

Human Resistin ELISA KIT
E42EH-93	EnoGene	96T/48T	Ask for price

Human Resistin ELISA kit
E22-HC136.48	EnoGene	48T	EUR 295

Human Resistin ELISA kit
E22-HC136.96	EnoGene	96T	EUR 395

Human Resistin ELISA Kit
E28L0045	EnoGene	96T	EUR 666.67

Human Resistin ELISA Kit
EK2351	SAB	96 tests	EUR 497

Human Resistin ELISA Kit
EHR0358	Abclonal	96Tests	EUR 625.2

Human Resistin ELISA kit
55R-E50	Fitzgerald	96 wells	EUR 715
Description: ELISA kit for the detection of Human Resistin in the research laboratory

Human Resistin ELISA kit
55R-1714	Fitzgerald	1 kit	EUR 717
Description: ELISA kit for the detection of Human Resistin in the research laboratory

Human Resistin ELISA kit
55R-2127	Fitzgerald	96 tests	EUR 825
Description: ELISA Kit for detection of Resistin in the research laboratory

Human Resistin ELISA KIT
CSB-E06884h-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Resistin ELISA KIT
1-CSB-E06884h	Cusabio	Ask for price Ask for price Ask for price	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

human Resistin ELISA KIT
CN-04165H1	ChemNorm	96T	EUR 530.4

human Resistin ELISA KIT
CN-04165H2	ChemNorm	48T	EUR 351.6

Human Resistin ELISA Kit
MBS008924-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Resistin ELISA Kit
MBS008924-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Resistin ELISA Kit
MBS008924-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Resistin ELISA Kit
MBS008924-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Human Resistin ELISA Kit
GWB-SKR059	GenWay Biotech	96 Tests	Ask for price

Human Resistin ELISA Kit
GWB-ZZD207	GenWay Biotech	1x96 well plate	Ask for price

Human Resistin ELISA kit
LF-EK50441	Abfrontier	1×96T	EUR 790.8

Human Resistin ELISA Kit
LF-EK70021	Abfrontier	1×96T	EUR 625.2

Human Resistin ELISA Kit
RK00139	Abclonal	96 Tests	EUR 280

Human Resistin ELISA Kit
SL1530Hu	Sunlong	96 Tests	EUR 468

Human Resistin ELISA Kit
MBS720386-48StripWellsCompetitive	MyBiosource	48-Strip-Wells-(Competitive)	EUR 485

Human Resistin ELISA Kit
MBS720386-48StripWellsSandwich	MyBiosource	48-Strip-Wells-(Sandwich)	EUR 485

Human Resistin ELISA Kit
MBS720386-5x96StripWellsCompetitive	MyBiosource	5x96-Strip-Wells-(Competitive)	EUR 3020

Human Resistin ELISA Kit
MBS720386-96StripWellsCompetitive	MyBiosource	96-Strip-Wells-(Competitive)	EUR 690

Human Resistin ELISA Kit
MBS720386-96StripWellsSandwich	MyBiosource	96-Strip-Wells-(Sandwich)	EUR 690

human Resistin ELISA Kit
MBS700822-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 4795

human Resistin ELISA Kit
MBS700822-24StripWellsLIMIT1	MyBiosource	24-Strip-Wells(LIMIT1)	EUR 275

human Resistin ELISA Kit
MBS700822-48StripWells	MyBiosource	48-Strip-Wells	EUR 415

human Resistin ELISA Kit
MBS700822-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2515

human Resistin ELISA Kit
MBS700822-96StripWells	MyBiosource	96-Strip-Wells	EUR 580

Human Resistin ELISA KIT
MBS9424817-5x96Tests	MyBiosource	5x96Tests	EUR 2225

Human Resistin ELISA KIT
MBS9424817-96Tests	MyBiosource	96Tests	EUR 485

Human Resistin ELISA Kit
MBS9426191-5x96Tests	MyBiosource	5x96Tests	EUR 2420

Human Resistin ELISA Kit
MBS9426191-96Tests	MyBiosource	96Tests	EUR 530

Human Resistin ELISA Kit
MBS762836-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3900

Human Resistin ELISA Kit
MBS762836-48StripWells	MyBiosource	48-Strip-Wells	EUR 340

Human Resistin ELISA Kit
MBS762836-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2045

Human Resistin ELISA Kit
MBS762836-96StripWells	MyBiosource	96-Strip-Wells	EUR 455

Human Resistin ELISA Kit
MBS824773-5x96Tests	MyBiosource	5x96Tests	EUR 2755

Human Resistin ELISA Kit
MBS824773-96Tests	MyBiosource	96Tests	EUR 620

Human Resistin ELISA Kit
MBS8244688-5x96Tests	MyBiosource	5x96Tests	EUR 2755

Human Resistin ELISA Kit
MBS8244688-96Tests	MyBiosource	96Tests	EUR 620

Human Resistin ELISA Kit
MBS8579201-48Tests	MyBiosource	48Tests	EUR 390

Human Resistin ELISA Kit
MBS8579201-5x96Tests	MyBiosource	5x96Tests	EUR 2275

Human Resistin ELISA Kit
MBS8579201-96Tests	MyBiosource	96Tests	EUR 495

Human Resistin ELISA KIT
MBS8506135-48Wells	MyBiosource	48Wells	EUR 390

Human Resistin ELISA KIT
MBS8506135-5x96Wells	MyBiosource	5x96Wells	EUR 2275

Human Resistin ELISA KIT
MBS8506135-96Wells	MyBiosource	96Wells	EUR 495

Human Resistin ELISA Kit
MBS824892-5x96Tests	MyBiosource	5x96Tests	EUR 2755

Human Resistin ELISA Kit
MBS824892-96Tests	MyBiosource	96Tests	EUR 620

Human Resistin ELISA Kit
MBS3800505-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Resistin ELISA Kit
MBS3800505-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Resistin ELISA Kit
MBS3800505-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Resistin ELISA Kit
MBS3800505-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Human Resistin ELISA Kit
MBS2885825-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3290

Human Resistin ELISA Kit
MBS2885825-48StripWells	MyBiosource	48-Strip-Wells	EUR 340

Human Resistin ELISA Kit
MBS2885825-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 1800

Human Resistin ELISA Kit
MBS2885825-96StripWells	MyBiosource	96-Strip-Wells	EUR 435

Human Resistin ELISA Kit
MBS9719285-48Tests	MyBiosource	48Tests	EUR 300

Human Resistin ELISA Kit
MBS9719285-5x48Tests	MyBiosource	5x48Tests	EUR 1365

Human Resistin ELISA Kit
MBS9719285-5x96Tests	MyBiosource	5x96Tests	EUR 1750

Human Resistin ELISA Kit
MBS9719285-96Tests	MyBiosource	96Tests	EUR 385

human Resistin ELISA KIT
201-12-0339	Shanghai Sunred Biological Technology	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Resistin (43-65) (Human) - RIA Kit
RK-028-39	PHOENIX PEPTIDE	125 tubes	EUR 1061.64

Resistin (Human) ELISA Kit
EKA51875-5x96T	Biomatik Corporation	5x96T	Ask for price

Resistin (Human) ELISA Kit
EKA51875-96T	Biomatik Corporation	96T	EUR 446.9

Resistin Human ELISA Kit
MBS355429-5x96Tests	MyBiosource	5x96Tests	EUR 2325

Resistin Human ELISA Kit
MBS355429-96Tests	MyBiosource	96Tests	EUR 515

Human Resistin (RETN) Protein
20-abx068871	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug

Human Resistin (RETN) Protein
20-abx651562	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug

Human Resistin (RETN) Protein
abx670217-25ug	Abbexa	25 ug	EUR 661.2

Human Resistin (RETN) Protein
abx068871-10g	Abbexa	10 µg	EUR 375

Human Resistin (RETN) Protein
abx068871-2g	Abbexa	2 µg	EUR 212.5

 

Analysis of two level of care applied sciences for measuring monoclonal antibody therapeutic-A concentrations in blood

Goal: Present blood monitoring strategies require pattern assortment and testing at a central lab, which might take days. Level of care (POC) gadgets with fast turnaround time can present another with quicker outcomes, permitting for real-time information main to raised therapy choices for sufferers.

Outcomes/Methodology: An assay to measure monoclonal antibody therapeutic-A was developed on two POC gadgets. Knowledge generated utilizing 75 serum samples (65 scientific & ten spiked samples) present correlative outcomes to the information generated utilizing Gyrolab expertise.

Conclusion: This case research makes use of a monoclonal antibody therapeutic-A focus assay for example to show the potential of POC applied sciences as a viable various to central lab testing with fast outcomes permitting for real-time decision-making.

Technology and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue

Though there’s ample proof that the superior glycation end-product (AGE) glucosepane contributes to age-related morbidities and diabetic issues, the affect of glucosepane modifications on proteins has not been extensively explored because of the lack of ample analytical instruments. Right here, we report the event of the primary polyclonal anti-glucosepane antibodies utilizing an artificial immunogen that accommodates the core bicyclic ring construction of glucosepane.

We examine the popularity properties of those antibodies by ELISAs involving an array of artificial AGE derivatives and decide them to be each high-affinity and selective in binding glucosepane. We then make use of these antibodies to picture glucosepane in getting old mouse retinae through immunohistochemistry. Our research show for the primary time accumulation of glucosepane throughout the retinal pigment epithelium, Bruch’s membrane, and choroid: all areas of the attention impacted by age-related macular degeneration.

Co-localization research additional counsel that glucosepane colocalizes with lipofuscin, which has beforehand been related to lysosomal dysfunction and has been implicated within the improvement of age-related macular degeneration, amongst different illnesses. We consider that the anti-glucosepane antibodies described on this research will show extremely helpful for inspecting the function of glycation in human well being and illness.

 

Reconstitution of an Anti-HER2 Antibody Paratope by Grafting Twin CDR-Derived Peptides Onto a Small Protein Scaffold

Goal-binding small proteins are promising alternate options to traditional monoclonal antibodies (mAbs), providing benefits when it comes to tissue penetration and manufacturing prices. Not too long ago, we developed a design technique to create small proteins known as fluctuation-regulated affinity proteins (FLAPs) consisting of a structurally immobilized peptide from the complementarity-determining area (CDR) loops of mAbs (CDR-derived peptide) and a protein scaffold.

As a result of mAb paratopes are normally composed of a number of CDRs, FLAPs with a number of binding peptides might have an enhanced target-binding functionality. Right here, we describe a method to create FLAPs bearing twin CDR-derived peptides (D-FLAPs) utilizing the anti-human epithelial progress issue receptor kind 2 (HER2) mAb trastuzumab as a foundation. Computationally chosen CDR-derived peptides had been first grafted onto two adjoining loops of the fibronectin kind III area (FN3) scaffold, yielding 80 D-FLAP candidates.

After computational screening primarily based on their similarity to the parental mAb with regard to the conformation of paratope residues, two candidates had been chosen. After additional analysis with ELISA, one D-FLAP with HYTTPP and GDGFYA peptides from CDR-L3 and CDR-H3 of the parental mAb, respectively, was discovered to bind HER2 with a dissociation fixed of 58 nM. Our technique applies to varied mAb medication and permits the rational design of small protein alternate options. This text is protected by copyright. All rights reserved.

Anti-Human LEC (CCL16)
MBS550695-01mg	MyBiosource	0.1mg	EUR 260

Anti-Human LEC (CCL16)
MBS550695-02mg	MyBiosource	0.2mg	EUR 335

Recombinant Human LEC
MBS7608806-005mg	MyBiosource	0.05mg	EUR 345

Recombinant Human LEC
MBS7608806-02mg	MyBiosource	0.2mg	EUR 635

Recombinant Human LEC
MBS7608806-1mg	MyBiosource	1mg	EUR 1800

Recombinant Human LEC
MBS7608806-5x1mg	MyBiosource	5x1mg	EUR 6955

Recombinant Human LEC (CCL16)
Z100325	ABM	25 µg	EUR 235
Description: CCL16 is a CC chemokine that specifically attracts lymphocytes, dendritic cells, and monocytes; increases their adhesive properties and has myelosuppressive activity. It is constitutively expressed in liver and is increased by interleukin 10 (IL-10) in activated monocytes. CCL16 is present in human plasma suggesting that it may be active outside hepatic tissue. CCR1, CCR2, CCR5, and CCR8 are the functional receptors of this chemokine.

Recombinant Human LEC (CCL16)
Z100329	ABM	1.0 mg	EUR 3900
Description: CCL16 is a CC chemokine that specifically attracts lymphocytes, dendritic cells, and monocytes; increases their adhesive properties and has myelosuppressive activity. It is constitutively expressed in liver and is increased by interleukin 10 (IL-10) in activated monocytes. CCL16 is present in human plasma suggesting that it may be active outside hepatic tissue. CCR1, CCR2, CCR5, and CCR8 are the functional receptors of this chemokine.

Recombinant Human LEC (CCL16)
MBS4159662-0025mg	MyBiosource	0.025mg	EUR 385

Recombinant Human LEC (CCL16)
MBS4159662-1mg	MyBiosource	1(mg)	EUR 4600

Recombinant Human LEC (CCL16)
MBS4159662-5x1mg	MyBiosource	5x1mg	EUR 20445

Human LEC (CCL16) Recombinant
MBS553045-0005mg	MyBiosource	0.005mg	EUR 165

Human LEC (CCL16) Recombinant
MBS553045-0025mg	MyBiosource	0.025mg	EUR 245

Anti-Human LEC/NCC-4 Antibody
102-P51G	ReliaTech	100 µg	EUR 245.7
Description: LEC or NCC-4 is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Human LEC/CCL16 Antibody Pair Set
ABPR-ZB293	Creative Diagnostics	5 plates, 15 plates	Ask for price
Description: Quantitative determination of Human LEC/CCL16

Anti-Human LEC Goat Polyclonal Antibody
TA328365	Origene Technologies GmbH	100 µg	Ask for price

Human LEC/NCC-4 (CCL16)
MBS692056-0005mg	MyBiosource	0.005mg	EUR 300

Human LEC/NCC-4 (CCL16)
MBS692056-002mg	MyBiosource	0.02mg	EUR 450

Human LEC/NCC-4 (CCL16)
MBS692056-5x002mg	MyBiosource	5x0.02mg	EUR 1725

Recombinant Human LEC (CCL16) Protein
PROTO15467-1	BosterBio	20ug	EUR 380.4
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Recombinant Human LEC/CCL16 protein
CD01396-5ug	Jiaxing Korain Biotech Ltd (BT Labs)	5ug	EUR 176
Description: Human CCL16, also called Liver-expressed chemokine (LEC), Monotactin-1 (MTN-1), IL-10-inducible chemokine and so on, is expressed by the CCL16 gene located on the chromosome 17 in humans. The gene encodes a 120 a.a. residue precursor protein with a 23 a.a. residue predicted signal peptide that is cleaved to generate a 97 a.a. residue mature protein. The protein is secreted by the liver, thymus, spleen cells and showing chemotactic activity for lymphocytes and monocytes but it is distantly related to other CC chemokines, exhibiting less than 30 % sequence identity. CCL16 is highly induced by IL-10, IFN-γ and bacterial lipopolysaccharide in monmcytes and signal through CCR1, CCR2, CCR5, and CCR8.

LEC/NCC-4 Human Recombinant
rAP-0241	Angio Proteomie	Inquiry	Ask for price

Human LEC Recombinant Protein Lyophilized
IHULECRLY5UG	Innovative research	each	EUR 341
Description: Human LEC Recombinant Protein Lyophilized

Human LEC Recombinant Protein Lyophilized
MBS8432637-INQUIRE	MyBiosource	INQUIRE	Ask for price

Biotinylated Anti-Human LEC Goat Polyclonal Antibody
TA328364	Origene Technologies GmbH	50 µg	Ask for price

LEC antibody
10R-L115A	Fitzgerald	500 ug	EUR 240
Description: Mouse monoclonal LEC antibody

LEC antibody
70R-LG003	Fitzgerald	50 ug	EUR 312
Description: Affinity purified Goat polyclonal LEC antibody

LEC antibody
MBS532318-05mg	MyBiosource	0.5mg	EUR 370

LEC antibody
MBS532318-5x05mg	MyBiosource	5x0.5mg	EUR 1525

LEC antibody
MBS535708-005mg	MyBiosource	0.05mg	EUR 465

LEC antibody
MBS535708-5x005mg	MyBiosource	5x0.05mg	EUR 1945

Recombinant Human LEC/NCC-4 (CCL16)
7-01792	CHI Scientific	5µg	Ask for price

Recombinant Human LEC/NCC-4 (CCL16)
7-01793	CHI Scientific	20µg	Ask for price

Recombinant Human LEC/NCC-4 (CCL16)
7-01794	CHI Scientific	1mg	Ask for price

Recombinant Human LEC/NCC-4 (CCL16)
HECCP-1601	Cyagen	5ug	Ask for price

Recombinant Human LEC/NCC-4 (CCL16)
MBS143272-0005mg	MyBiosource	0.005mg	EUR 240

Recombinant Human LEC/NCC-4 (CCL16)
MBS143272-002mg	MyBiosource	0.02mg	EUR 310

Recombinant Human LEC/NCC-4 (CCL16)
MBS143272-1mg	MyBiosource	1mg	EUR 2880

Recombinant Human LEC/NCC-4 (CCL16)
MBS143272-5x1mg	MyBiosource	5x1mg	EUR 12630

LEC / CCL16 / HCC4 Monoclonal antibody [Clone: LEC-14]
LEC-14-100ug	Biologicals	100 ug	EUR 141.79
Description: Identify and measure human LEC. Marker for inflammatory processes.

LEC / CCL16 / HCC4 Monoclonal antibody [Clone: LEC-14]
LEC-14-1mg	Biologicals	1 mg	EUR 897.6
Description: Identify and measure human LEC. Marker for inflammatory processes.

LEC / CCL16 / HCC4 Monoclonal antibody [Clone: LEC-14]
LEC-14-500ug	Biologicals	500 ug	EUR 479.6
Description: Identify and measure human LEC. Marker for inflammatory processes.

LEC / CCL16 / HCC4 Monoclonal antibody [Clone: LEC-57]
LEC-57-100ug	Biologicals	100 ug	EUR 141.79
Description: Identify and measure human LEC. Marker for inflammatory processes.

LEC / CCL16 / HCC4 Monoclonal antibody [Clone: LEC-57]
LEC-57-1mg	Biologicals	1 mg	EUR 897.6
Description: Identify and measure human LEC. Marker for inflammatory processes.

LEC / CCL16 / HCC4 Monoclonal antibody [Clone: LEC-57]
LEC-57-500ug	Biologicals	500 ug	EUR 479.6
Description: Identify and measure human LEC. Marker for inflammatory processes.

LEC/CCL16 Matched ELISA Antibody Pair Set, Human
MBS8118261-15Plates	MyBiosource	15Plates	EUR 600

LEC/CCL16 Matched ELISA Antibody Pair Set, Human
MBS8118261-5Plates	MyBiosource	5Plates	EUR 345

LEC/CCL16 Matched ELISA Antibody Pair Set, Human
MBS8118261-5x15Plates	MyBiosource	5x15Plates	EUR 2755

HCC-4, LEC, NCC-4, CCL16, human
RC315-27	Bio Basic	5ug	EUR 125.26

Human LEC/NCC-4 (CCL16) Recombinant Protein
100-060	ReliaTech	20 µg	EUR 196.35
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Human LEC/NCC-4 (CCL16) Recombinant Protein
100-060S	ReliaTech	5 µg	EUR 92.4
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

LEC (CCL16) (NM_004590) Human Over-expression Lysate
LS006360	BosterBio	100ug	EUR 628
Description: Transient overexpression lysate of chemokine (C-C motif) ligand 16 (CCL16)

CCL16 LEC/NCC-4 Human Recombinant Protein
PROTO15467	BosterBio	Regular: 20ug	EUR 380.4
Description: CCL16 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 97 amino acids and having a molecular mass of 11.2 kDa. ;The CCL16 is purified by proprietary chromatographic techniques.

LEC/CCL16 Protein, Human, Recombinant (His Tag)
MBS8120314-005mg	MyBiosource	0.05mg	EUR 340

LEC/CCL16 Protein, Human, Recombinant (His Tag)
MBS8120314-1mg	MyBiosource	1mg	EUR 2530

LEC/CCL16 Protein, Human, Recombinant (His Tag)
MBS8120314-5x1mg	MyBiosource	5x1mg	EUR 11240

LEC/CCL16 Protein, Human, Recombinant (His Tag)
MBS8120315-005mg	MyBiosource	0.05mg	EUR 340

LEC/CCL16 Protein, Human, Recombinant (His Tag)
MBS8120315-5x005mg	MyBiosource	5x0.05mg	EUR 1380

LEC, NCC-4, Human (Liver-Expressed Chemokine)
MBS635010-0005mg	MyBiosource	0.005mg	EUR 340

LEC, NCC-4, Human (Liver-Expressed Chemokine)
MBS635010-002mg	MyBiosource	0.02mg	EUR 490

LEC, NCC-4, Human (Liver-Expressed Chemokine)
MBS635010-5x002mg	MyBiosource	5x0.02mg	EUR 2055

LEC Chemokine(LEC66) Antibody
BNC040066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC040066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC040067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC040067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC810066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC810066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC810067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC810067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC940066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC940066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC940067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC940067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC880066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC880066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC880067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC880067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC430066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC430066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC430067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC430067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC050066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC050066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC050067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC050067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC470066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC470066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC470067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC470067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC400066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC400066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC400067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC400067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC550066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC550066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC550067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC550067-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC610066-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody
BNC610066-500	Biotium	500uL	EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody
BNC610067-100	Biotium	100uL	EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL