Analysis of T and B Cell Epitopes to Predict the Risk of de novo Donor-Specific Antibody

Correlation Between Anti-Myelin Proteolipid Protein (PLP) Antibodies and Illness Severity in A number of Sclerosis Sufferers With PLP Response-Permissive HLA Varieties

Essentially the most distinguished pathological options of a number of sclerosis (MS) are demyelination and neurodegeneration. The precise pathogenesis of MS is unknown, however it’s typically thought to be a T cell-mediated autoimmune illness. Rising proof, nonetheless, means that different elements of the immune system, significantly B cells and antibodies, contribute to the cumulative CNS injury and worsening incapacity that characterize the illness course in lots of sufferers.

We’ve got beforehand described strongly elevated T cell reactivity to an extracellular area of essentially the most ample CNS myelin protein, myelin proteolipid protein (PLP) in folks with MS. The present paper addresses the query of whether or not this area of PLP can also be a goal of autoantibodies in MS. Right here we present that serum ranges of isotype-switched anti-PLP181-230 particular antibodies are considerably elevated in sufferers with MS in comparison with wholesome people and sufferers with different neurological ailments.

These anti-PLP181-230 antibodies can even live-label PLP-transfected cells, confirming that they will acknowledge native PLP expressed on the cell floor. Importantly, the antibodies are solely elevated in sufferers who carry HLA molecules that permit robust T cell responses to PLP.

In that subgroup of sufferers, there’s a optimistic correlation between the degrees of anti-PLP181-230 antibodies and the severity of MS. These outcomes display that anti-PLP antibodies have probably necessary roles to play within the pathogenesis of MS.

toxhistory

toxhistory

Galectin-1, Human

E34M148H 5 μg
EUR 155

Galectin-1 Human

GWB-DAB7E1 0.05 mg Ask for price

Galectin-1, Human

MBS8575305-0005mg 0.005mg
EUR 245

Galectin-1, Human

MBS8575305-5x0005mg 5x0.005mg
EUR 940

Mouse anti Human Galectin-1 Antibody, Mouse MAb

MBS2543309-006mL 0.06mL
EUR 250

Mouse anti Human Galectin-1 Antibody, Mouse MAb

MBS2543309-012mL 0.12mL
EUR 370

Mouse anti Human Galectin-1 Antibody, Mouse MAb

MBS2543309-02mL 0.2mL
EUR 550

Human Galectin-1 (Gal-1) Antibody

30005-05111 150 ug
EUR 215

Human Galectin( Galectin) Elisa Kit

EK711568 96 Wells
EUR 0.18

RABBIT ANTI HUMAN GALECTIN-3:Biotin

MBS222930-005mg 0.05mg
EUR 655

RABBIT ANTI HUMAN GALECTIN-3:Biotin

MBS222930-5x005mg 5x0.05mg
EUR 2780

Rabbit Anti-Human Galectin-1

102-PA131 100ug
EUR 240

Anti-Human Galectin-1 Antibody

102-P131 100 µg
EUR 245.7
Description: Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and anti-inflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.

Anti-Human Galectin-1 Antibody

102-PA131AG 50 µg
EUR 157.5
Description: Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and antiinflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.

Anti-Human Galectin-1 Antibody

102-PA131S 100 µg
EUR 126
Description: Galectin-1, also known as L14, BHL and galaptin, is a monomeric or homodimeric prototype galectin that is expressed in a variety of cells and tissues including muscle, heart, liver, prostate, lymph nodes, spleen, thymus, placenta, testis, retina, macrophages, B cells, T cells, dendritic cells, and tumor cells. It preferentially binds laminin, fibronectin, 90K/Mac2BP, CD45, CD43, CD7, CD2, CD3, and ganglioside GM1. Galectin-1 modulates cell growth and proliferation, either positively or negatively, depending on the cell type and activation status. It controls cell survival by inducing apoptosis of activated T cells and immature thymocytes. It modulates cytokine secretion by inducing Th2 type cytokines and inhibiting proinflammatory cytokine production. Galectin1 can also modulate cel-lcell as well as cell-lmatrix interactions and depending on the cell type and developmental stage, promote cell attachment or detachment. Galectin-1 has immunosuppressive and antiinflammatory properties and has been shown to suppress acute and chronic inflammation and autoimmunity. Human and mouse galectin1 share about 88% amino acid sequence similarity.

human anti-human galectin-3 mAb(2D)

E4A09H10-2D 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(5F)

E4A09H10-5F 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(A5)

E4A09H10-A5 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(G2)

E4A09H10-G2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(H3)

E4A09H10-H3 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human galectin-3 mAb(T1)

E4A09H10-T1 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human Galectin-1 (LGALS1)

1-CSB-EP012882HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Human Galectin-1 (LGALS1)

1-CSB-EP012882HUb1
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Mouse anti Human Galectin-1/LGALS1 Monoclonal Antibody

MBS2543310-006mL 0.06mL
EUR 250

Mouse anti Human Galectin-1/LGALS1 Monoclonal Antibody

MBS2543310-012mL 0.12mL
EUR 370

Mouse anti Human Galectin-1/LGALS1 Monoclonal Antibody

MBS2543310-02mL 0.2mL
EUR 550

human anti-human galectin-3 mAb(N13)

E4A09H10-N13 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human Galectin-1 Protein

PRP1033-100g 100 µg
EUR 309

Human Galectin-1 Protein

PRP1033-1mg 1 mg
EUR 1099

Human Galectin-1 Protein

PRP1033-20g 20 µg
EUR 79

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543912-006mL 0.06mL
EUR 250

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543912-012mL 0.12mL
EUR 370

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543912-02mL 0.2mL
EUR 550

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543913-006mL 0.06mL
EUR 250

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543913-012mL 0.12mL
EUR 370

Rabbit anti Human Galectin-1/LGALS1  Monoclonal Antibody

MBS2543913-02mL 0.2mL
EUR 550

Anti Human Galectin-3 Polyclonal Antibody

KH040 each
EUR 778.8
Description: The Anti Human Galectin-3 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

Human Galectin-3(Galectin-3)ELISA Kit

YLA0216HU-48T 48T Ask for price

Human Galectin-3(Galectin-3)ELISA Kit

YLA0216HU-96T 96T Ask for price

Recombinant Human Galectin-1

7-00427 10µg Ask for price

Recombinant Human Galectin-1

7-00428 50µg Ask for price

Recombinant Human Galectin-1

7-00429 1mg Ask for price

Recombinant Human Galectin-1

AP60482 100ug
EUR 449

Recombinant Human Galectin-1

HEOPP-0710 10ug Ask for price

RECOMBINANT HUMAN GALECTIN-1

GWB-BEA2B0 0.05 mg Ask for price

Recombinant Human Galectin-1

cyt-544-10g 10µg
EUR 60

Recombinant Human Galectin-1

cyt-544-1mg 1mg
EUR 1350

Recombinant Human Galectin-1

cyt-544-50g 50µg
EUR 145

Recombinant Human Galectin-1

MBS143303-001mg 0.01mg
EUR 240

Recombinant Human Galectin-1

MBS143303-005mg 0.05mg
EUR 310

Recombinant Human Galectin-1

MBS143303-1mg 1mg
EUR 1515

Recombinant Human Galectin-1

MBS143303-5x1mg 5x1mg
EUR 6485

RECOMBINANT HUMAN GALECTIN-1

MBS232407-005mg 0.05mg
EUR 500

RECOMBINANT HUMAN GALECTIN-1

MBS232407-5x005mg 5x0.05mg
EUR 2070

Recombinant Human Galectin-1

P1229-.01 10ug
EUR 108.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Galectin-1

P1229-.1 10X10ug
EUR 450.4
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Galectin-1

P1229-.5 50X10ug
EUR 1010.4
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Galectin-1

MBS9420409-002mg 0.02mg
EUR 285

Recombinant Human Galectin-1

MBS9420409-01mg 0.1mg
EUR 470

Recombinant Human Galectin-1

MBS9420409-1mg 1mg
EUR 1785

Recombinant Human Galectin-1

MBS9420409-5x1mg 5x1mg
EUR 7885

Recombinant Human Galectin-1

MBS966052-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human Galectin-1

MBS966052-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human Galectin-1

MBS966052-1mgEColi 1mg(E-Coli)
EUR 1425

Recombinant Human Galectin-1

MBS966052-5x1mgEColi 5x1mg(E-Coli)
EUR 6215

anti- Galectin-1 antibody

FNab03314 100µg
EUR 606.3
Description: Antibody raised against Galectin-1

anti- Galectin-1 antibody

FNab03315 100µg
EUR 658.5
Description: Antibody raised against Galectin-1

Anti- Galectin-1 Antibody

GWB-6F6392 0.1 mg Ask for price

Human Galectin 1 Protein

20-abx066725
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Galectin-1 Antibody Pair Set

ABPR-ZB244 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human Galectin-1

Galectin-1, human recombinant

4648-10 each
EUR 170.4

Galectin-1, human recombinant

4648-1000 each
EUR 1977.6

Galectin-1, human recombinant

4648-50 each
EUR 314.4

Galectin-1 Human Recombinant

rAP-2252 Inquiry Ask for price

Galectin-1 (human), (recombinant)

MBS567229-01mg 0.1mg
EUR 750

Galectin-1 (human), (recombinant)

MBS567229-5x01mg 5x0.1mg
EUR 3320

Anti-Human Galectin-1 Azide Free

MBS335796-02mg 0.2mg
EUR 290

Anti-Human Galectin-1 Azide Free

MBS335796-05mg 0.5mg
EUR 555

Anti-Human Galectin-1 Azide Free

MBS335796-5x05mg 5x0.5mg
EUR 2465

Anti-Human Galectin-1 Azide Free

MBS335797-02mg 0.2mg
EUR 290

Anti-Human Galectin-1 Azide Free

MBS335797-05mg 0.5mg
EUR 555

Anti-Human Galectin-1 Azide Free

MBS335797-5x05mg 5x0.5mg
EUR 2465

Human Galectin-1 ELISA Kit

EK5323 96 tests
EUR 599

Human Galectin-1 ELISA Kit

IHULGALS1KT each
EUR 702
Description: Human Galectin-1 ELISA Kit

Human Galectin-1 ELISA Kit

MBS765403-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Galectin-1 ELISA Kit

MBS765403-48StripWells 48-Strip-Wells
EUR 340

Human Galectin-1 ELISA Kit

MBS765403-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Galectin-1 ELISA Kit

MBS765403-96StripWells 96-Strip-Wells
EUR 455

Human Galectin-1 ELISA Kit

MBS8414441-1Kit 1Kit
EUR 755

Human Galectin-1 ELISA Kit

MBS8414441-5x1Kit 5x1Kit
EUR 3455

Human Galectin-1 ELISA Kit

MBS2883188-10x96StripWells 10x96-Strip-Wells
EUR 3290

Human Galectin-1 ELISA Kit

MBS2883188-48StripWells 48-Strip-Wells
EUR 340

Human Galectin-1 ELISA Kit

MBS2883188-5x96StripWells 5x96-Strip-Wells
EUR 1800

Human Galectin-1 ELISA Kit

MBS2883188-96StripWells 96-Strip-Wells
EUR 435

Recombinant Human Galectin 1

MBS7609301-005mg 0.05mg
EUR 345

Recombinant Human Galectin 1

MBS7609301-02mg 0.2mg
EUR 635

Recombinant Human Galectin 1

MBS7609301-1mg 1mg
EUR 1800

Recombinant Human Galectin 1

MBS7609301-5x1mg 5x1mg
EUR 6955

Human Galectin-1 (LEG1) Protein

abx690252-100g 100 µg
EUR 837.5

Human Galectin-1 (LEG1) Protein

abx690252-20g 20 µg
EUR 350

Human Galectin 1 CLIA Kit

MBS8425460-INQUIRE INQUIRE Ask for price

Human Galectin 1 (GAL1) ELISA

KT-15605 96 tests
EUR 952

Human Galectin-1 (LGALS1) Protein

abx670211-50ug 50 ug
EUR 661.2

Galectin-1, 1-135aa, Human, E Coli

MBS203386-002mg 0.02mg
EUR 190

Galectin-1, 1-135aa, Human, E Coli

MBS203386-01mg 0.1mg
EUR 280

Galectin-1, 1-135aa, Human, E Coli

MBS203386-05mg 0.5mg
EUR 570

Galectin-1, 1-135aa, Human, E Coli

MBS203386-5x05mg 5x0.5mg
EUR 2325

Mouse Monoclonal anti-human Galectin-1

hAP-1228 50ug
EUR 400

Sheep Polyclonal anti-Human Galectin-1

hAP-5905 50ug
EUR 400

Human Galectin 1 ELISA kit

E01A4669 96T
EUR 700
Description: ELISA

Human Galectin 1 ELISA kit

E01G0038-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Galectin 1 ELISA kit

E01G0038-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Galectin 1 ELISA kit

E01G0038-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Galectin 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Galectin 1 ELISA Kit

MBS029650-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Galectin 1 ELISA Kit

MBS029650-48StripWells 48-Strip-Wells
EUR 550

Human Galectin 1 ELISA Kit

MBS029650-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Galectin 1 ELISA Kit

MBS029650-96StripWells 96-Strip-Wells
EUR 765

Human Galectin 1 ELISA Kit

IHUGAL1KT each
EUR 667
Description: Human Galectin 1 ELISA Kit

Human Galectin 1 ELISA Kit

MBS721030-48StripWellsCompetitive 48-Strip-Wells-(Competitive)
EUR 485

Human Galectin 1 ELISA Kit

MBS721030-48StripWellsSandwich 48-Strip-Wells-(Sandwich)
EUR 485

Human Galectin 1 ELISA Kit

MBS721030-5x96StripWellsCompetitive 5x96-Strip-Wells-(Competitive)
EUR 3020

Human Galectin 1 ELISA Kit

MBS721030-96StripWellsCompetitive 96-Strip-Wells-(Competitive)
EUR 690

Human Galectin 1 ELISA Kit

MBS721030-96StripWellsSandwich 96-Strip-Wells-(Sandwich)
EUR 690

Human Galectin 1 ELISA Kit

MBS8248373-5x96Tests 5x96Tests
EUR 2880

Human Galectin 1 ELISA Kit

MBS8248373-96Tests 96Tests
EUR 645

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-48StripWells 48-Strip-Wells
EUR 550

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Galectin-1 (GAL-1) ELISA Kit

MBS3800380-96StripWells 96-Strip-Wells
EUR 765

Human Galectin-3

MBS691554-001mg 0.01mg
EUR 300

Human Galectin-3

MBS691554-005mg 0.05mg
EUR 450

Human Galectin-3

MBS691554-5x005mg 5x0.05mg
EUR 1725

Galectin-10, Human

E34M155H 5 μg
EUR 155

Galectin-12, Human

E34M156H 5 μg
EUR 155

Galectin-13, Human

E34M157H 5 μg
EUR 155

Galectin-14, Human

E34M158H 5 μg
EUR 155

Galectin-16, Human

E34M159H 5 μg
EUR 155

Galectin-10, Human

MBS8575312-0005mg 0.005mg
EUR 245

Galectin-10, Human

MBS8575312-5x0005mg 5x0.005mg
EUR 940

Galectin-12, Human

MBS8575313-0005mg 0.005mg
EUR 245

Galectin-12, Human

MBS8575313-5x0005mg 5x0.005mg
EUR 940

Galectin-13, Human

MBS8575314-0005mg 0.005mg
EUR 245

Galectin-13, Human

MBS8575314-5x0005mg 5x0.005mg
EUR 940

Galectin-14, Human

MBS8575315-0005mg 0.005mg
EUR 245

Galectin-14, Human

MBS8575315-5x0005mg 5x0.005mg
EUR 940

Galectin-16, Human

MBS8575316-0005mg 0.005mg
EUR 245

Galectin-16, Human

MBS8575316-5x0005mg 5x0.005mg
EUR 940

Recombinant Human Galectin-1(LGALS1)

AP70493 1mg
EUR 1978

Recombinant Human Galectin-1 (LGALS1)

CSB-EP012882HU 1598 mg Ask for price

Recombinant Human Galectin-1 (LGALS1)

CSB-EP012882HUb1 1599 mg Ask for price

Recombinant Human Galectin-1 (LGALS1)

Z101845 15 µg
EUR 105
Description: Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.

Recombinant Human Galectin-1 (LGALS1)

Z101847 100 µg
EUR 270
Description: Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.

Recombinant Human Galectin-1 (LGALS1)

Z101849 1.0 mg
EUR 1135
Description: Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.

Recombinant Human Galectin-1 (LGALS1)

MBS7115230-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human Galectin-1 (LGALS1)

MBS7115230-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human Galectin-1 (LGALS1)

MBS7115230-1mgEColi 1mg(E-Coli)
EUR 1425

Recombinant Human Galectin-1 (LGALS1)

MBS7115230-5x1mgEColi 5x1mg(E-Coli)
EUR 6215

Recombinant Human Galectin-1 (LGALS1)

MBS4159798-0015mg 0.015mg
EUR 255

Recombinant Human Galectin-1 (LGALS1)

MBS4159798-01mg 0.1mg
EUR 430

Recombinant Human Galectin-1 (LGALS1)

MBS4159798-1mg 1mg
EUR 1425

Recombinant Human Galectin-1 (LGALS1)

MBS4159798-5x1mg 5x1mg
EUR 6165

Galectin-2, Human

E34M149H 5 μg
EUR 155

Galectin-3, Human

E34M150H 5 μg
EUR 155

Galectin-4, Human

E34M151H 5 μg
EUR 155

Galectin-7, Human

E34M152H 5 μg
EUR 155

Galectin-8, Human

E34M153H 5 μg
EUR 155

Galectin-9, Human

E34M154H 5 μg
EUR 155

Galectin-3 Human

GWB-1FDCC0 0.05 mg Ask for price

Galectin-2, Human

MBS8575306-0005mg 0.005mg
EUR 245

Galectin-2, Human

MBS8575306-5x0005mg 5x0.005mg
EUR 940

Galectin-3, Human

MBS8575307-0005mg 0.005mg
EUR 245

Galectin-3, Human

MBS8575307-5x0005mg 5x0.005mg
EUR 940

Galectin-4, Human

MBS8575308-0005mg 0.005mg
EUR 245

Galectin-4, Human

MBS8575308-5x0005mg 5x0.005mg
EUR 940

Galectin-7, Human

MBS8575309-0005mg 0.005mg
EUR 245

Galectin-7, Human

MBS8575309-5x0005mg 5x0.005mg
EUR 940

Galectin-8, Human

MBS8575310-0005mg 0.005mg
EUR 245

Galectin-8, Human

MBS8575310-5x0005mg 5x0.005mg
EUR 940

Galectin-9, Human

MBS8575311-0005mg 0.005mg
EUR 245

Galectin-9, Human

MBS8575311-5x0005mg 5x0.005mg
EUR 940

Human Galectin-1 Recombinant Protein

100-175 50 µg
EUR 196.35
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Human Galectin-1 Recombinant Protein

100-175S 10 µg
EUR 92.4
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Human Galectin-1 Recombinant Protein

400-015 50 µg
EUR 126
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with beta-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Recombinant Human Galectin-1 Protein

E40KMP1041 20ug
EUR 495

Recombinant Human Galectin-1 Protein

PROTP09382-1 50ug
EUR 380.4
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Recombinant Human Galectin-1 protein

CD01752-10ug 10ug
EUR 176
Description: Human Galectin-1 also named BHL, Galaptin, GBP, L- 14 and LGALS1, is belonging to the galectins family and it is encoded by the LGALS1 gene in human. Galectin-1 is expressed by the endometrial stromal cells throughout the menstrual cycle. Galectin-1 contains a single carbohydrate recognition domain through which it can bind glycans both as a monomer and as a homodimer. Dimers are non-covenantly bound and will spontaneou sly disassociate in low concentration. Galectin -1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin - 1 is thought to play a role in the immunosuppression required for a successful pregnancy. Human Galectin-1 shares 88 %-90 % amino acid sequence identity with rat and mouse.

Recombinant Human Galectin-1 Protein

MBS9139610-002mg 0.02mg
EUR 190

Recombinant Human Galectin-1 Protein

MBS9139610-005mg 0.05mg
EUR 260

Recombinant Human Galectin-1 Protein

MBS9139610-01mg 0.1mg
EUR 360

Recombinant Human Galectin-1 Protein

MBS9139610-5x01mg 5x0.1mg
EUR 1445

Human Galectin-1 (Gal-1) Antibody (Biotin Conjugate)

30005-05121 150 ug
EUR 315

Human Galectin-1 ELISA ELISA Kit

E16HE0311 96T
EUR 1000

Human Galectin 1 (LGALS1) Protein

abx066725-100g 100 µg
EUR 512.5

Human Galectin 1 (LGALS1) Protein

abx066725-10g 10 µg
EUR 212.5

Human Galectin 1 (LGALS1) Protein

abx066725-50g 50 µg
EUR 362.5

 

Lupus Antibody Mimicking Diminished Plasmatic Coagulation in a Affected person With Atrial Fibrillation and Ischemic Stroke

Background: Lupus anticoagulant (LA) owns procoagulant properties in vivo and prolongs phospholipid-dependent clotting occasions in vitro. The extended in vitro clotting time may be misinterpreted as a bleeding dysfunction. In some instances, it’s essential to differentiate LA-associated in vitro modifications from in vivo coagulation issue deficiency. On this case, we used completely different laboratory testing in a affected person with ischemic stroke and lowered prothrombin time (PT) to determine an in-vitro impact of LA excluding an in-vivo bleeding dysfunction.

Strategies: The exercise of varied coagulation elements was evaluated each with recombinant thromboplastin Innovin (Siemens Healthcare) and reagent tissue extracted thromboplastin Thromborel® (Siemens Healthcare). Furthermore, a 1:1 plasma mixing check with normal plasma was carried out. As a way to exclude the interplay of tromboplastin and LA thromboplastin, an unbiased international coagulation check, thromboelastography, was used. Diluted-Russel-Viper-Venom (dRVVT) assay was utilized to detect the presence of LA detection.

Outcomes: The exercise of a number of coagulation elements measured with recombinant thromboplastin Innovin (Siemens Healthcare) confirmed a lowered exercise of the next coagulation elements: Issue V (20.9%), Issue VII (23.8%), Issue X (19.7%) and worldwide normalized ratio (INR) of two.33. Re-assessment of the issue’s exercise with one other reagent tissue extracted thromboplastin Thromborel® (Siemens Healthcare) confirmed a normalization of INR and issue’s exercise compared to thromboplastin reagent Innovin®: Issue V (77%), Issue VII (45.4%), Issue X (64.2%), and INR of 1.28. A plasma mixing research with 1:1 normal plasma revealed lowered (<50%) normalization of INR in addition to coagulation issue’s exercise confirming a LA-inhibitor within the affected person plasma. Diagnostic LA testing was additionally carried out with dRVVT assay exhibiting a considerably extended (112.Eight s) check time. Thromboelastography revealed no abnormalities.

Conclusions: Totally different thromboplastin reagents and plasma mixing assessments in addition to thromboplastin unbiased coagulation assessments could also be useful to distinguish LA and in vitro modifications from in vivo issue deficiency in sufferers with LA.

 

 

Evaluation of T and B Cell Epitopes to Predict the Threat of de novo Donor-Particular Antibody (DSA) Manufacturing After Kidney Transplantation: A Two-Heart Retrospective Cohort Research

  • Threat prediction of de novodonor particular antibody (DSA) could be crucial for long run graft consequence after organ transplantation. The aim of this research was to elucidate the affiliation of eplet mismatches and predicted not directly recognizable HLA epitopes (PIRCHE) scores with de novo DSA manufacturing.
  • Our retrospective cohort research enrolled 691 dwelling donor kidney transplantations. HLA-A, B, DRB and DQB eplet mismatches and PIRCHE scores (Four digit of HLA-A, B, DR, and DQ) had been decided by HLA matchmaker (ver 2.1) and PIRCHE-II Matching Service, respectively.
  • Weak correlation between eplet mismatches and PIRCHE scores was recognized, though each measurements had been related to classical HLA mismatches. Class II (DRB+DQB) eplet mismatches had been considerably correlated with the incidence of de novoclass II (DR/DQ) DSA manufacturing [8/235 (3.4%) in eplet mismatch ≤ 13 vs. 92/456 (20.2%) in eplet mismatch ≥ 14, p < 0.001]. PIRCHE scores had been additionally considerably correlated with de novo class II DSA manufacturing [26/318 (8.2%) in PIRCHE ≤ 175 vs. 74/373 (19.8%) in PIRCHE ≥ 176, p < 0.001].
  • Sufferers with low ranges of each class II eplet mismatches and PIRCHE scores developed de novoclass II DSA solely in 4/179 (2.2%). Evaluation of T cell and B cell epitopes can present a helpful data on the design of individualized immunosuppression regimens for prevention of de novo DSA manufacturing after kidney transplantation.

 

Mouse Anti-Rat Podoplanin

MBS690143-5x01mg 5x0.1mg
EUR 1725

Mouse Anti Human Podoplanin

MBS140296-0005mg 0.005mg
EUR 240

Mouse Anti Human Podoplanin

MBS140296-002mg 0.02mg
EUR 310

Mouse Anti Human Podoplanin

MBS140296-01mg 0.1mg
EUR 610

Mouse Anti Human Podoplanin

MBS140296-5x01mg 5x0.1mg
EUR 2405

MOUSE ANTI HUMAN PODOPLANIN

MBS212743-01mg 0.1mg
EUR 450

MOUSE ANTI HUMAN PODOPLANIN

MBS212743-5x01mg 5x0.1mg
EUR 1840

Hamster anti Podoplanin (mouse)

103-M40 100ug
EUR 297.6

Mouse Anti-Human Podoplanin

MBS690117-0025mg 0.025mg
EUR 310

Mouse Anti-Human Podoplanin

MBS690117-5x0025mg 5x0.025mg
EUR 1110

Mouse Anti-Human Podoplanin

MBS690586-01mg 0.1mg
EUR 450

Mouse Anti-Human Podoplanin

MBS690586-5x01mg 5x0.1mg
EUR 1725

Mouse Anti-Human Podoplanin

MBS690680-0025mg 0.025mg
EUR 310

Mouse Anti-Human Podoplanin

MBS690680-5x0025mg 5x0.025mg
EUR 1110

Mouse Anti-Human Podoplanin

MBS690759-01mg 0.1mg
EUR 450

Mouse Anti-Human Podoplanin

MBS690759-5x01mg 5x0.1mg
EUR 1725

Mouse Anti-Human Podoplanin

MBS690992-005mg 0.05mg
EUR 430

Mouse Anti-Human Podoplanin

MBS690992-5x005mg 5x0.05mg
EUR 1645

Mouse Anti-Human Podoplanin

MBS692357-005mg 0.05mg
EUR 450

Mouse Anti-Human Podoplanin

MBS692357-5x005mg 5x0.05mg
EUR 1725

Mouse Anti-Human Podoplanin

MBS692358-005mg 0.05mg
EUR 450

Mouse Anti-Human Podoplanin

MBS692358-5x005mg 5x0.05mg
EUR 1725

Mouse anti Podoplanin-Biotin (human)

101-MBi40 50ug
EUR 297.6

Hamster anti Podoplanin-Biotin (mouse)

103-MBi40 50ug
EUR 297.6

Podoplanin Mouse mAb

A18776 100μL
EUR 719.13

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-0005mg 0.005mg
EUR 240

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-002mg 0.02mg
EUR 310

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-01mg 0.1mg
EUR 610

Mouse Anti Human Podoplanin clone P56F7AT

MBS146676-5x01mg 5x0.1mg
EUR 2405

Mouse Podoplanin, soluble

MBS691731-0005mg 0.005mg
EUR 250

Mouse Podoplanin, soluble

MBS691731-5x0005mg 5x0.005mg
EUR 835

Anti-Human/Mouse PDPN/Podoplanin Antibody

MBS1569238-01mg 0.1mg
EUR 405

Anti-Human/Mouse PDPN/Podoplanin Antibody

MBS1569238-5x01mg 5x0.1mg
EUR 1520

Recombinant Mouse Podoplanin

MBS7610672-005mg 0.05mg
EUR 345

Recombinant Mouse Podoplanin

MBS7610672-02mg 0.2mg
EUR 635

Recombinant Mouse Podoplanin

MBS7610672-1mg 1mg
EUR 1800

Recombinant Mouse Podoplanin

MBS7610672-5x1mg 5x1mg
EUR 6955

Mouse Monoclonal anti-Rat Podoplanin Antibody

xAP-0897 100ug
EUR 280

Mouse Podoplanin ELISA kit

E01A24381 96T
EUR 700
Description: ELISA

Mouse Podoplanin ELISA kit

E03P0082-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit

E03P0082-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit

E03P0082-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA Kit

IMSPDPNKT each
EUR 752
Description: Mouse Podoplanin ELISA Kit

Mouse Podoplanin ELISA Kit

MBS725552-10x96StripWells 10x96-Strip-Wells
EUR 5685

Mouse Podoplanin ELISA Kit

MBS725552-48StripWells 48-Strip-Wells
EUR 485

Mouse Podoplanin ELISA Kit

MBS725552-5x96StripWells 5x96-Strip-Wells
EUR 3020

Mouse Podoplanin ELISA Kit

MBS725552-96StripWells 96-Strip-Wells
EUR 690

Mouse Podoplanin ELISA Kit

MBS2884556-10x96StripWells 10x96-Strip-Wells
EUR 4080

Mouse Podoplanin ELISA Kit

MBS2884556-48StripWells 48-Strip-Wells
EUR 390

Mouse Podoplanin ELISA Kit

MBS2884556-5x96StripWells 5x96-Strip-Wells
EUR 2220

Mouse Podoplanin ELISA Kit

MBS2884556-96StripWells 96-Strip-Wells
EUR 520

Hamster Anti-Mouse Podoplanin

MBS690646-01mg 0.1mg
EUR 450

Hamster Anti-Mouse Podoplanin

MBS690646-5x01mg 5x0.1mg
EUR 1725

Hamster Anti-Mouse Podoplanin

MBS690790-005mg 0.05mg
EUR 430

Hamster Anti-Mouse Podoplanin

MBS690790-5x005mg 5x0.05mg
EUR 1645

Anti-Mouse Podoplanin Antibody

103-M552 100 µg
EUR 399
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Anti-Mouse Podoplanin Antibody

103-PA40 200 µg
EUR 204.75
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Anti-Mouse Podoplanin Antibody

103-PA40S 100 µg
EUR 126
Description: Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46% aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Mouse Podoplanin (PDPN) Protein

20-abx650139
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Podoplanin (PDPN) Protein

abx694266-10nmol 10 nmol
EUR 700

Mouse Podoplanin (PDPN) Protein

abx694266-5nmol 5 nmol
EUR 462.5

Mouse Podoplanin (PDPN) Protein

abx650139-100g 100 µg
EUR 537.5

Mouse Podoplanin (PDPN) Protein

abx650139-10g 10 µg
EUR 212.5

Mouse Podoplanin (PDPN) Protein

abx650139-50g 50 µg
EUR 375

Mouse Monoclonal Podoplanin Antibody

TA327727 1 ml Ask for price

anti- Podoplanin antibody

FNab06598 100µg
EUR 702
Description: Antibody raised against Podoplanin

anti- Podoplanin antibody

FNab06599 100µg
EUR 702
Description: Antibody raised against Podoplanin

Mouse Podoplanin (PDPN) CLIA Kit

20-abx493858
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit

abx571749-96tests 96 tests
EUR 943.2

Mouse Podoplanin (PDPN) ELISA Kit

20-abx154564
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu 96T
EUR 475
Description: tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu-48T 48T
EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

DLR-PDPN-Mu-96T 96T
EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

DL-PDPN-Mu 96T
EUR 453
Description: tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

EK8596 96Т
EUR 799

Mouse Podoplanin (PDPN) ELISA Kit

EKN47838-48T 48T
EUR 389.62

Mouse Podoplanin (PDPN) ELISA Kit

EKN47838-5x96T 5x96T
EUR 2643.85

Mouse Podoplanin (PDPN) ELISA Kit

EKN47838-96T 96T
EUR 556.6

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-48Tests 48 Tests
EUR 325
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-96Tests 96 Tests
EUR 610
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN)ELISA kit

YLA0596MO-48T 48T Ask for price

Mouse Podoplanin (PDPN)ELISA kit

YLA0596MO-96T 96T Ask for price

Mouse Podoplanin, Pdpn ELISA KIT

ELI-06723m 96tests
EUR 736

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-1096T 10*96T
EUR 4122

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-48wells 48 wells
EUR 300

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-596T 5*96T
EUR 2061

Mouse Podoplanin,PDPN ELISA KIT

E1437Mo-96wells 96 wells
EUR 458

Mouse Podoplanin (PDPN) ELISA Kit

EKU06727-48T 48T
EUR 571.55

Mouse Podoplanin (PDPN) ELISA Kit

EKU06727-5x96T 5x96T
EUR 3878.38

Mouse Podoplanin (PDPN) ELISA Kit

EKU06727-96T 96T
EUR 816.5

Mouse Podoplanin(PDPN)ELISA kit

QY-E21215 96T
EUR 433.2

Mouse Podoplanin (PDPN) ELISA Kit

RK13459 96T
EUR 280

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-48T 48T
EUR 487.52
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-48Tests 48 Tests
EUR 668.4

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-96T 96T
EUR 696.47
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RDR-PDPN-Mu-96Tests 96 Tests
EUR 928.8

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-48T 48T
EUR 464.3
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-48Tests 48 Tests
EUR 639.6

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-96T 96T
EUR 663.3
Description: tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

RD-PDPN-Mu-96Tests 96 Tests
EUR 888

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-10x96wellstestplate 10x96-wells test plate
EUR 5834.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-1x48wellstestplate 1x48-wells test plate
EUR 585.7
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-1x96wellstestplate 1x96-wells test plate
EUR 785.28
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

SEC719Mu-5x96wellstestplate 5x96-wells test plate
EUR 3173.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit

4-SEC719Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-48T 48T
EUR 325
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN) ELISA Kit

AE28131MO-96T 96T
EUR 610
Description: Mouse (Mus musculus)

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-48StripWells 48-Strip-Wells
EUR 550

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Podoplanin (PDPN) ELISA Kit

MBS9309796-96StripWells 96-Strip-Wells
EUR 765

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-10x96StripWells 10x96-Strip-Wells
EUR 3955

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-48StripWells 48-Strip-Wells
EUR 305

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-5x96StripWells 5x96-Strip-Wells
EUR 2005

Mouse Podoplanin (PDPN) ELISA Kit

MBS1601033-96StripWells 96-Strip-Wells
EUR 475

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-10x96StripWells 10x96-Strip-Wells
EUR 5455

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-24StripWells 24-Strip-Wells
EUR 365

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-48StripWells 48-Strip-Wells
EUR 550

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-5x96StripWells 5x96-Strip-Wells
EUR 2985

Mouse Podoplanin (PDPN) ELISA Kit

MBS2020020-96StripWells 96-Strip-Wells
EUR 740

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-10x96Tests 10x96Tests
EUR 5375

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-48Tests 48Tests
EUR 470

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-5x96Tests 5x96Tests
EUR 2755

Mouse Podoplanin (PDPN) ELISA Kit

MBS4501762-96Test 96Test
EUR 620

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-10x96StripWells 10x96-Strip-Wells
EUR 6255

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-48StripWells 48-Strip-Wells
EUR 445

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-5x96StripWells 5x96-Strip-Wells
EUR 3290

Mouse Podoplanin (PDPN) ELISA Kit

MBS2803565-96StripWells 96-Strip-Wells
EUR 730

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-10x96StripWells 10x96-Strip-Wells
EUR 5160

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-48StripWells 48-Strip-Wells
EUR 450

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-5x96StripWells 5x96-Strip-Wells
EUR 2645

Mouse Podoplanin (PDPN) ELISA Kit

MBS455766-96StripWells 96-Strip-Wells
EUR 595

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-10x96StripWells 10x96-Strip-Wells
EUR 3215

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-24StripWells 24-Strip-Wells
EUR 255

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-48StripWells 48-Strip-Wells
EUR 340

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-5x96StripWells 5x96-Strip-Wells
EUR 1675

Mouse Podoplanin (PDPN) ELISA Kit

MBS2704635-96StripWells 96-Strip-Wells
EUR 430

Recombinant Mouse Podoplanin Protein

MBS8305318-001mg 0.01mg
EUR 220

Recombinant Mouse Podoplanin Protein

MBS8305318-005mg 0.05mg
EUR 450

Recombinant Mouse Podoplanin Protein

MBS8305318-05mg 0.5mg
EUR 1905

Recombinant Mouse Podoplanin Protein

MBS8305318-5x05mg 5x0.5mg
EUR 8485

Mouse PDPN (Podoplanin) ELISA Kit

EKE61859-5x96T 5x96T
EUR 3124.08

Mouse PDPN (Podoplanin) ELISA Kit

EKE61859-96T 96T
EUR 657.7

Mouse PDPN(Podoplanin) ELISA Kit

ELK7080-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PDPN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PDPN. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PDPN, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PDPN in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse PDPN(Podoplanin) ELISA Kit

ELK7080-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PDPN. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PDPN. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PDPN, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PDPN in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse PDPN(Podoplanin) ELISA Kit

RE2052M-48wells 48 wells
EUR 116.55

Mouse PDPN(Podoplanin) ELISA Kit

RE2052M-96wells 96 wells
EUR 161.55

Mouse Pdpn / Podoplanin ELISA Kit

E2095m 96T
EUR 776

Mouse PDPN (Podoplanin) ELISA Kit

MBS8806057-10x96StripWells 10x96-Strip-Wells
EUR 3130

Mouse PDPN (Podoplanin) ELISA Kit

MBS8806057-48StripWells 48-Strip-Wells
EUR 350

Mouse PDPN (Podoplanin) ELISA Kit

MBS8806057-5x96StripWells 5x96-Strip-Wells
EUR 1710

Mouse PDPN (Podoplanin) ELISA Kit

MBS8806057-96StripWells 96-Strip-Wells
EUR 445

Mouse PDPN (Podoplanin) ELISA Kit

MBS2516017-10x96Tests 10x96Tests
EUR 4060

Mouse PDPN (Podoplanin) ELISA Kit

MBS2516017-24Tests 24Tests
EUR 265

Mouse PDPN (Podoplanin) ELISA Kit

MBS2516017-48Test 48Test
EUR 450

Mouse PDPN (Podoplanin) ELISA Kit

MBS2516017-5x96Test 5x96Test
EUR 2265

Mouse PDPN (Podoplanin) ELISA Kit

MBS2516017-96Tests 96Tests
EUR 535

Mouse PDPN(Podoplanin) ELISA Kit

RE2052M-48wellsplate 48-wells plate
EUR 126

Mouse PDPN(Podoplanin) ELISA Kit

RE2052M-96wellsplate 96-wells plate
EUR 180

Recombinant Mouse Podoplanin (C-Fc)

CU73-10ug 10ug
EUR 157.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)

CU73-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)

CU73-500ug 500ug
EUR 1399.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)

CU73-50ug 50ug
EUR 327.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Mouse Podoplanin, PDPN GENLISA ELISA

KLM1437 1 x 96 wells
EUR 341

Podoplanin (PDPN) Polyclonal Antibody (Mouse)

4-PAC719Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN)

ELISA kit for Mouse Podoplanin (PDPN)

KTE70775-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)

KTE70775-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Podoplanin (PDPN)

KTE70775-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Hamster Monoclonal anti-mouse Podoplanin

mAP-0062 100ug
EUR 250

Anti-Rat Podoplanin Antibody

104-M40 100 µg
EUR 189
Description: Podoplanin is a well-recognized lymphatic endothelium marker, which can be used to reliably distinguish lymphatic vessels from blood vessels. It was originally discovered in kidney podocytes. This mouse monoclonal antibody (IgG) against rat podoplanin works well for immunohistochemistry with formalin-fixed paraffin embedded sections. This antibody also can be used in FACS sorting.

Anti- Podoplanin Human Antibody

GWB-F131C7 0.2 mg Ask for price

ELISA kit for Mouse PDPN (Podoplanin)

E-EL-M2409 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse PDPN (Podoplanin)

ELK7080 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), PE

4-PAC719Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with PE.

Rabbit Anti-Human Podoplanin

102-PA40 100ug
EUR 240

Recombinant Mouse Podoplanin (Pdpn), partial

MBS1362245-005mgBaculovirus 0.05mg(Baculovirus)
EUR 990

Recombinant Mouse Podoplanin (Pdpn), partial

MBS1362245-005mgMammalianCell 0.05mg(Mammalian-Cell)
EUR 1215

Recombinant Mouse Podoplanin (Pdpn), partial

MBS1362245-05mgEColi 0.5mg(E-Coli)
EUR 990

Recombinant Mouse Podoplanin (Pdpn), partial

MBS1362245-05mgYeast 0.5mg(Yeast)
EUR 1215

Recombinant Mouse Podoplanin (Pdpn), partial

MBS1362245-1mgEColi 1mg(E-Coli)
EUR 1390

Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761

CABT-L2919-100uL500uL 100 uL, 500 uL
EUR 602.4

Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761

CABT-L2919 100 µl, 500 µl Ask for price
Description: Mouse

Anti-Human Podoplanin Antibody

101-M40-FITC 50 µg Ask for price
Description: Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 36 kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid (aa) precursor (NP_006465). It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 207228) and a short cytoplasmic tail (aa 229-238). The ECD contains abundant Ser/Thr residues that could serve as potential Olinked glycosolation sites. The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47% aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin-like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin-induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Anti-Human Podoplanin Antibody

101-M40-PE 50 µg Ask for price
Description: Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 36 kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid (aa) precursor (NP_006465). It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 207228) and a short cytoplasmic tail (aa 229-238). The ECD contains abundant Ser/Thr residues that could serve as potential Olinked glycosolation sites. The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47% aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin-like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin-induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Anti-Human Podoplanin Antibody

101-M40S-FITC 25 µg Ask for price
Description: Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 36 kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid (aa) precursor (NP_006465). It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 207228) and a short cytoplasmic tail (aa 229-238). The ECD contains abundant Ser/Thr residues that could serve as potential Olinked glycosolation sites. The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47% aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin-like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin-induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.

Anti-Human Podoplanin Antibody

101-M40S-PE 25 µg Ask for price
Description: Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 36 kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid (aa) precursor (NP_006465). It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 207228) and a short cytoplasmic tail (aa 229-238). The ECD contains abundant Ser/Thr residues that could serve as potential Olinked glycosolation sites. The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47% aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin-like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin-induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.